Insulin Release, Ca2+ Fluxes and Calmodulin Content of Pancreatic Islets in Aging Rats
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 211)
Although previous reports have indicated the β-cells from collagenase-isolated islets of aging rats give a smaller secretory-response to glucose or leucine stimulation than islets from young rats,1,2 the underlying mechanism for this phenomenon is still not clear. In the present study we have investigated the effects of age on the calmodulin content, Ca2+ movements and insulin release.
KeywordsPancreatic Islet Insulin Release Basal Insulin Collagenase Digestion Induce Insulin Secret
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© Plenum Press, New York 1986