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Insulin Release, Ca2+ Fluxes and Calmodulin Content of Pancreatic Islets in Aging Rats

  • J. J. Osuna
  • R. Rubio
  • E. Rodriguez
  • C. Osorio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

Although previous reports have indicated the β-cells from collagenase-isolated islets of aging rats give a smaller secretory-response to glucose or leucine stimulation than islets from young rats,1,2 the underlying mechanism for this phenomenon is still not clear. In the present study we have investigated the effects of age on the calmodulin content, Ca2+ movements and insulin release.

Keywords

Pancreatic Islet Insulin Release Basal Insulin Collagenase Digestion Induce Insulin Secret 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    E. P. Reaven, G. Gold, and G. M. Reaven, Effect of age on glucose-stimulated insulin release by the beta-cell of the rat, J. Clin. Invest. 64:591 (1979).PubMedCrossRefGoogle Scholar
  2. 2.
    E. P. Reaven, G. Gold and G. M. Reaven, Effect of age on leucineinduced insulin secretion by the beta-cell, J. Gerontol. 35:324 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. J. Osuna
    • 1
  • R. Rubio
    • 1
  • E. Rodriguez
    • 1
  • C. Osorio
    • 1
  1. 1.Departamento de Fisiologia y Bioquimica, Facultad de MedicinaUniversidad de GranadaGranadaSpain

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