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Comparision of Stimulus-Secretion Coupling in Normal and ob/ob (Norwich Colony) Mouse Islets of Langerhans

  • A. M. Scott
  • C. M. Dawson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

The Norwich colony of ob/ob mice has been compared with albino mice. The electrical response of the islet membrane to high glucose stimulation is different in the 2 types of mice, 22.2 mM glucose generating continuous spike activity in normal but producing bursts of activity in ob/ob mouse islets. The magnitude and dynamics of the insulin and lactate response to high glucose are similar in the 2 types of mice, although the absolute amounts released are higher in the ob/ob mice. Potassium permeability in islets from normal mice is inhibited by quinine, which potentiates glucose-induced insulin release. Quinine does not potentiate glucose-induced insulin release in ob/ob islets but in the absence of glucose, 100 μm quinine induces electrical activity in such islets.

Keywords

Electrical Activity Insulin Release Mouse Islet Glucose Stimulation Normal Islet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. M. Scott
    • 1
  • C. M. Dawson
    • 1
  1. 1.Dept. of Biophysics, School of Biological SciencesUniversity of East AngliaNorwichEngland

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