Abstract
The Norwich colony of ob/ob mice has been compared with albino mice. The electrical response of the islet membrane to high glucose stimulation is different in the 2 types of mice, 22.2 mM glucose generating continuous spike activity in normal but producing bursts of activity in ob/ob mouse islets. The magnitude and dynamics of the insulin and lactate response to high glucose are similar in the 2 types of mice, although the absolute amounts released are higher in the ob/ob mice. Potassium permeability in islets from normal mice is inhibited by quinine, which potentiates glucose-induced insulin release. Quinine does not potentiate glucose-induced insulin release in ob/ob islets but in the absence of glucose, 100 μm quinine induces electrical activity in such islets.
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© 1986 Plenum Press, New York
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Scott, A.M., Dawson, C.M. (1986). Comparision of Stimulus-Secretion Coupling in Normal and ob/ob (Norwich Colony) Mouse Islets of Langerhans. In: Atwater, I., Rojas, E., Soria, B. (eds) Biophysics of the Pancreatic β-Cell. Advances in Experimental Medicine and Biology, vol 211. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5314-0_41
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DOI: https://doi.org/10.1007/978-1-4684-5314-0_41
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