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Pulsatile Insulin Release and Electrical Activity from Single ob/ob Mouse Islets of Langerhans

  • L. M. Rosario
  • I. Atwater
  • A. M. Scott
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

Since Ca-action potentials were first measured in β-cells, it has been assumed that the resultant Ca2+ influx provides a critical Ca2+-dependent step in the events leading to insulin secretion.4,6. The correlation between electrical activity and insulin release remained indirect, however, since membrane potentials were recorded from single β-cells within an isolated islet and insulin release was measured from batches of collagenase isolated islets (usually more than 100) or from the perfused pancreas (containing over 1000 islets).

Keywords

Membrane Potential Electrical Activity Insulin Release High Glucose Concentration Mouse Islet 
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References

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • L. M. Rosario
    • 1
  • I. Atwater
    • 1
  • A. M. Scott
    • 2
  1. 1.Laboratory of Cell Biology and Genetics, NIDDKNational Institutes of HealthBethesdaUSA
  2. 2.Department of Biophysics, School of Biological SciencesUniversity of East AngliaNorwichEngland

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