A Potassium Channel Modulated by Glucose Metabolism in Rat Pancreatic β-Cells
It is well established that glucose-stimulated insulin release from the pancreatic β-cell is associated with the initiation of electrical activity (see recent review by Henquin & Meissner10). Microelectrode recordings have shown that in the absence of glucose the β-cell is electrically silent. Increasing plasma glucose depolarises the membrane by an amount that is dependent on the glucose concentration and electrical activity is initiated when this depolarisation exceeds a threshold level. There is considerable evidence that the initial slow depolarisation induced by glucose results from a decrease in the resting potassium permeability of the membrane5,8,14 as a consequence of glucose metabolism9).
KeywordsSingle Channel Current Channel Open Probability Increase Plasma Glucose Potassium Permeability Open State Probability
Unable to display preview. Download preview PDF.