Cyclic Amp-Antagonist, a Second Messenger for Insulin Action, Inhibits Glucose-Stimulated Insulin Secretion in Isolated Islets of Chinese Hamsters
The intracellular regulator cAMP-antagonist (cPIP) appears well suited as a mediator of insulin action: cPIP has been isolated, after stimulation with insulin and adrenalin, from rat livers at a concentration of 0.6 × 10-7 M.6 Similarly it can be isolated from other tissues as heart, fat, kidney, muscle, brain, spleen, suggesting that cPIP is an ubiquituous regulator. Dose-response curves show increasing cPIP synthesis with increasing insulin concentrations. This dose-response relationship parallels the receptor binding of insulin. Evidence exists that cPIP is composed of prostaglandin E, myo-inositol and phosphate as primary constituents. Therefore, it has been named prostaglandyl-inositol cyclic phosphate (cPIP).7,8.
KeywordsInsulin Secretion Insulin Action Isolate Islet Biphasic Insulin Phosphoprotein Phosphatase
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- 7.H. K. Wasner, Prostaglandyl-inositol cyclic phosphate, a second messenger for insulin, Abstr. 2nd Int. Symp. Ins. Recp., Rome, Italy (1983).Google Scholar