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Cyclic Amp-Antagonist, a Second Messenger for Insulin Action, Inhibits Glucose-Stimulated Insulin Secretion in Isolated Islets of Chinese Hamsters

  • H.-J. Partke
  • H. K. Wasner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

The intracellular regulator cAMP-antagonist (cPIP) appears well suited as a mediator of insulin action: cPIP has been isolated, after stimulation with insulin and adrenalin, from rat livers at a concentration of 0.6 × 10-7 M.6 Similarly it can be isolated from other tissues as heart, fat, kidney, muscle, brain, spleen, suggesting that cPIP is an ubiquituous regulator. Dose-response curves show increasing cPIP synthesis with increasing insulin concentrations. This dose-response relationship parallels the receptor binding of insulin. Evidence exists that cPIP is composed of prostaglandin E, myo-inositol and phosphate as primary constituents. Therefore, it has been named prostaglandyl-inositol cyclic phosphate (cPIP).7,8.

Keywords

Insulin Secretion Insulin Action Isolate Islet Biphasic Insulin Phosphoprotein Phosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H.-J. Partke
    • 1
  • H. K. Wasner
    • 1
  1. 1.Diabetes Research InstituteDusseldorfFederal Republic of Germany

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