Cyclic Amp-Antagonist, a Second Messenger for Insulin Action, Inhibits Glucose-Stimulated Insulin Secretion in Isolated Islets of Chinese Hamsters

  • H.-J. Partke
  • H. K. Wasner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


The intracellular regulator cAMP-antagonist (cPIP) appears well suited as a mediator of insulin action: cPIP has been isolated, after stimulation with insulin and adrenalin, from rat livers at a concentration of 0.6 × 10-7 M.6 Similarly it can be isolated from other tissues as heart, fat, kidney, muscle, brain, spleen, suggesting that cPIP is an ubiquituous regulator. Dose-response curves show increasing cPIP synthesis with increasing insulin concentrations. This dose-response relationship parallels the receptor binding of insulin. Evidence exists that cPIP is composed of prostaglandin E, myo-inositol and phosphate as primary constituents. Therefore, it has been named prostaglandyl-inositol cyclic phosphate (cPIP).7,8.


Insulin Secretion Insulin Action Isolate Islet Biphasic Insulin Phosphoprotein Phosphatase 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H.-J. Partke
    • 1
  • H. K. Wasner
    • 1
  1. 1.Diabetes Research InstituteDusseldorfFederal Republic of Germany

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