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Interdependency of Ca2+ Availability and Cyclic AMP Generation in the Pancreatic β-Cell

  • I. Valverde
  • P. Garcia-Morales
  • M. Saceda
  • W. J. Malaisse
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

At least ten distinct coupling factors or second messengers may participate in the process of insulin release from the pancreatic β-cell. They include, inter alia, reducing equivalents, protons, ATP, diacylglycerol, inositol 1,4,5-triphosphate, polyamine and obviously cyclic AMP and cytosolic ionized calcium. This report deals briefly with the inter-dependency of Ca2+ availability and cyclic AMP generation in the pancreatic β-cell.

Keywords

Adenylate Cyclase Insulin Release Adenylate Cyclase Activity Intact Islet Vacuolar System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • I. Valverde
    • 1
    • 2
  • P. Garcia-Morales
    • 1
    • 2
  • M. Saceda
    • 1
    • 2
  • W. J. Malaisse
    • 1
    • 2
  1. 1.Fundacion Jimenez DiazUniversidad Autonoma de MadridMadridSpain
  2. 2.Laboratory of Experimental MedicineBrussels Free UniversityBrusselsBelgium

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