The Insulin Secretory Granule: Features and Functions in Common with Other Endocrine Granules

  • J. C. Hutton
  • M. Peshavaria
  • H. W. Davidson
  • K. Grimaldi
  • R. Pogge Von Strandmann
  • K. Siddle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


The insulin secretory granule of the pancreatic β-cell although simple in morphology is a complex biochemical entity containing upwards of a hundred different proteins (for review see (1)). Besides the primary secreted products which constitute about 80% of the total granule protein, there are minor cosecreted peptides, proteases involved in processing of proinsulin, ion pumps in the granule membrane and granule surface proteins involved in the movement of the organelle in the cell and its fusion with the plasma membrane during exocytosis.


Secretory Granule Islet Cell Tumor Granule Membrane Chromaffin Granule Insulin Granule 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. C. Hutton
    • 1
  • M. Peshavaria
    • 1
  • H. W. Davidson
    • 1
  • K. Grimaldi
    • 1
  • R. Pogge Von Strandmann
    • 1
  • K. Siddle
    • 1
  1. 1.Department of Clinical Biochemistry, Addenbrooke’s HospitalUniversity of CambridgeCambridgeUK

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