Electrophysiological Evidence for Histaminergic Modulation of Pancreatic β-Cell Function

  • A. Marques
  • R. Ferrer
  • C. Ripoll
  • B. Soria
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


Although it is known that amines affect insulin secretion, their effects on glucose-induced insulin secretion are difficult to interpret for several reasons: 1) differential effects of alpha- and beta-receptor stimulation by catecholamines, 2) induction of catecholamine secretion by serotonin, 3) changes of capillary blood flow by histamine or 4) degranula-tion of β-cells with a marked dilatation of the rough endoplasmic reticulum, induced by the histamine and serotonin antagonist cyproheptadine. Membrane potential recording provides a direct assay for the effects of these substances on pancreatic β-cell membrane properties. This technique has been successfully used to further understand the effects of catecholamines on the β-cell membrane7. The aim of the present study was to determine the role of the putative neurotransmitter, histamine, on the control of membrane potential in the mouse pancreatic β-cell.


Capillary Blood Flow Transient Inhibition Culture Dorsal Root Ganglion Membrane Potential Recording Inhibitory Synaptic Potential 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. Marques
    • 1
  • R. Ferrer
    • 1
  • C. Ripoll
    • 1
  • B. Soria
    • 1
  1. 1.Departamento de FisiologiaFacultad de MedicinaAlicanteSpain

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