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Electrophysiological Evidence for Histaminergic Modulation of Pancreatic β-Cell Function

  • A. Marques
  • R. Ferrer
  • C. Ripoll
  • B. Soria
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

Although it is known that amines affect insulin secretion, their effects on glucose-induced insulin secretion are difficult to interpret for several reasons: 1) differential effects of alpha- and beta-receptor stimulation by catecholamines, 2) induction of catecholamine secretion by serotonin, 3) changes of capillary blood flow by histamine or 4) degranula-tion of β-cells with a marked dilatation of the rough endoplasmic reticulum, induced by the histamine and serotonin antagonist cyproheptadine. Membrane potential recording provides a direct assay for the effects of these substances on pancreatic β-cell membrane properties. This technique has been successfully used to further understand the effects of catecholamines on the β-cell membrane7. The aim of the present study was to determine the role of the putative neurotransmitter, histamine, on the control of membrane potential in the mouse pancreatic β-cell.

Keywords

Capillary Blood Flow Transient Inhibition Culture Dorsal Root Ganglion Membrane Potential Recording Inhibitory Synaptic Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. Marques
    • 1
  • R. Ferrer
    • 1
  • C. Ripoll
    • 1
  • B. Soria
    • 1
  1. 1.Departamento de FisiologiaFacultad de MedicinaAlicanteSpain

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