Modelling the β-Cell Electrical Activity

  • J. A. Bangham
  • P. A. Smith
  • P. C. Croghan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


A considerable body of quantitative information is emerging on the processes involved in stimulus-secretion by the β-cells of the islet of Langerhans. Many variables are involved and the relationships between them are complex. However, it is possible to quantify these relationships by producing mathematical models. Such models are based on simple physico-chemical principles and provide a convenient quantitative catalogue of relevant data. However in general they are non-linear and too complex for intuition alone to give the insight necessary to predict their properties. The alternative is to solve the equations numerically with the help of a computer. This approach has contributed to the quantitative description of for example purkinje fibres27,32, cardiac muscle13,3, epithelia22, bursting pacemaker neuron34 and a start has been made with the β-cell5,25,21,36.


Intracellular Calcium Concentration Pancreatic Islet Cell Mouse Islet Potassium Conductance Calcium Efflux 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. A. Bangham
    • 1
  • P. A. Smith
    • 1
  • P. C. Croghan
    • 1
  1. 1.Department of Biophysics, School of Biological SciencesUniversity of East AngliaNorwichEngland

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