Graded Spike Electrogenesis in Mouse Pancreatic β-Cells

  • B. Soria
  • Rosa Ferrer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


It is well established that the islet of Langerhans is responsible for the synthesis and secretion of insulin, glucagon and somatostatin. These hormones are produced in cells with distinct morphology and different topological distribution within the islet.20 While 88% of the islet volume is comprised of centrally located insulin secreting β-cells, glucagon secreting α-cells appear to concentrate in the outer cell layers.19 α-cells and β-cells constitute a morphological and functional unit.9,16,19


Spike Amplitude Large Spike Small Spike Islet Volume Electrotonic Spread 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • B. Soria
    • 1
  • Rosa Ferrer
    • 1
  1. 1.Departamento de Fisiologia, Facultad de MedicinaUniversidad de AlicanteAlicanteSpain

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