The Role of Anions in the Regulation of Insulin Secretion
Previous studies have shown that glucose-induced insulin release is inhibited by substitution of Cl- with non-permeant mono-valent anions such as isethionate,9,10–13 para-aminohippurate,11 or methyl sulphate.13 The precise mechanism behind this apparent Cl- dependence is unclear but the demonstration of a strong correlation between radioactive Cl- efflux from prelabelled islets and insulin release may indicate that Cl- transport in the β-cell is important for the regulation of insulin release.10,11 The present paper concerns the basic question, whether glucose-induced insulin release is strictly Cl--dependent or whether it rather shows anion selectivity. To this end, a study has been undertaken to measure the effects of a number of anions on insulin release and to compare the secretory effects of anions with their capacity to interfere with islet 45Ca2+ uptake.
KeywordsInsulin Secretion Insulin Release Secretory Effect Anion Selectivity Monovalent Anion
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