Contribution of Isotope Flux Studies to Understanding the Mechanism of the β-Cell Membrane

  • P. C. Croghan
  • C. M. Dawson
  • A. M. Scott
  • J. A. Bangham
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


The membrane potential of the animal cell membrane is determined principally by the diffusion of ions. Such a diffusion potential is determined by the concentrations of the diffusing (electrogenic) ions on either side of the membrane and by the permeability of the membrane to these ions. In the resting membrane, the permeability of the K+ ion is usually the dominant factor and depolarization of the membrane is caused by a reduction in K+ permeability and/or an increase in the permeability of other ions such as Na+ and/or Ca2+. These changes in membrane potential play a key role in the function of various cell types, including the pancreatic β-cell, where they seem to initiate processes leading ultimately to insulin release.


Membrane Potential Insulin Release Permeability Coefficient Efflux Rate Mouse Islet 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. C. Croghan
    • 1
  • C. M. Dawson
    • 1
  • A. M. Scott
    • 1
  • J. A. Bangham
    • 1
  1. 1.Department of Biophysics, School of Biological SciencesUniversity of East AngliaNorwichEngland

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