Stimulation of Insulin Release by Organic Calcium-Agonists
The concentration of ionized calcium in the cytosol of the pancreatic β-cell is thought to play a critical role in the regulation of insulin secretion. We have recently been able to document in isolated pancreatic endocrine cells removed from normal rats that an increase in extracellular D-glucose concentration provokes a rapid and sustained increase in cytosolic Ca2+ activity1. Several factors could contribute to this increase in cytosolic Ca2+ concentration, including facilitated Ca2+ influx into the β-cell and, possibly, changes in either Ca2+ outflow or Ca2+ intracellular distribution. The present note refers to the stimulation of insulin release by organic calcium-agonists3,5. Our results support the view that the gating of Ca2+ channels represents an efficient modality for stimulation of insulin secretion.
KeywordsInsulin Secretion Insulin Release Efficient Modality Pancreatic Endocrine Cell Insulin Output
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- 1.M. Deleers, M. Mahy, and W.J. Malaisse, Glucose increases cytosolic Ca2+ activity in pancreatic islet cells, Biochem.Internat. 10:97 (1985).Google Scholar