Stimulation of Insulin Release by Organic Calcium-Agonists

  • F. Malaisse-Lagae
  • A. Sener
  • W. J. Malaisse
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


The concentration of ionized calcium in the cytosol of the pancreatic β-cell is thought to play a critical role in the regulation of insulin secretion. We have recently been able to document in isolated pancreatic endocrine cells removed from normal rats that an increase in extracellular D-glucose concentration provokes a rapid and sustained increase in cytosolic Ca2+ activity1. Several factors could contribute to this increase in cytosolic Ca2+ concentration, including facilitated Ca2+ influx into the β-cell and, possibly, changes in either Ca2+ outflow or Ca2+ intracellular distribution. The present note refers to the stimulation of insulin release by organic calcium-agonists3,5. Our results support the view that the gating of Ca2+ channels represents an efficient modality for stimulation of insulin secretion.


Insulin Secretion Insulin Release Efficient Modality Pancreatic Endocrine Cell Insulin Output 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • F. Malaisse-Lagae
    • 1
  • A. Sener
    • 1
  • W. J. Malaisse
    • 1
  1. 1.Laboratory of Experimental MedicineBrussels Free UniversityBrusselsBelgium

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