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Effects of Verapamil and Nifedipine on Glucose-Induced Electrical Activity in Pancreatic β-Cells

  • M. Vasseur
  • A. Debuyser
  • M. Joffre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)

Abstract

It has been known for many years that calcium plays a key role in the stimulus-secretion coupling of the and β-cell. Glucose induced-insulin release is thought to be triggered by an increase in the cytosolic calcium concentration which appears partially related to the gating of Ca-channels, located at the plasma membrane. Experiments with Ca-channel blockers have confirmed this hypothesis: D600, Verapamil and Nifedipine cause a dose-dependent inhibition of the glucose-induced insulin release2,3,4.

Keywords

Calcium Antagonist Slow Wave Silent Phase Spike Frequency Potassium Citrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. Vasseur
    • 1
  • A. Debuyser
    • 1
  • M. Joffre
    • 1
  1. 1.Physiologie Animale CNRS U. A. 290“Biomembranes” U. E. R. SciencesPoitiers CedesFrance

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