Effects of Verapamil and Nifedipine on Glucose-Induced Electrical Activity in Pancreatic β-Cells
It has been known for many years that calcium plays a key role in the stimulus-secretion coupling of the and β-cell. Glucose induced-insulin release is thought to be triggered by an increase in the cytosolic calcium concentration which appears partially related to the gating of Ca-channels, located at the plasma membrane. Experiments with Ca-channel blockers have confirmed this hypothesis: D600, Verapamil and Nifedipine cause a dose-dependent inhibition of the glucose-induced insulin release2,3,4.
KeywordsCalcium Antagonist Slow Wave Silent Phase Spike Frequency Potassium Citrate
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