Effects of Verapamil and Nifedipine on Glucose-Induced Electrical Activity in Pancreatic β-Cells

  • M. Vasseur
  • A. Debuyser
  • M. Joffre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 211)


It has been known for many years that calcium plays a key role in the stimulus-secretion coupling of the and β-cell. Glucose induced-insulin release is thought to be triggered by an increase in the cytosolic calcium concentration which appears partially related to the gating of Ca-channels, located at the plasma membrane. Experiments with Ca-channel blockers have confirmed this hypothesis: D600, Verapamil and Nifedipine cause a dose-dependent inhibition of the glucose-induced insulin release2,3,4.


Calcium Antagonist Slow Wave Silent Phase Spike Frequency Potassium Citrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    P. Lebrun, W. J. Malaisse, and A. Herchuelz, Effect of calcium antagonists on potassium conductance in islet cells, Biochem. Pharmacol. 30:3291 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    W. J. Malaisse and C. Boschero, Calcium antagonists and islet function. Effect of Nifedipine, Hormone Res 8:203 (1977).PubMedCrossRefGoogle Scholar
  3. 3.
    W. J. Malaisse, G. Devis, D. G. Pipeleers, and G. Somers, Calcium antagonists and islet function. Effect of D600, Diabetologia 12:77 (1976).PubMedCrossRefGoogle Scholar
  4. 4.
    W. J. Malaisse, A. Herchuelz, J. Levy and A. Sener, Calcium antagonists and islet function. The possible site of action of Verapamil, Biochem. Pharmacol. 26:735 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    E. K. Matthews and Y. Sakamoto, Electrical characteristics of pancreatic islet cells, J. Physiol. 246:421 (1975).PubMedGoogle Scholar
  6. 6.
    H. P. Meissner and H. Schmelz, Membrane potential of beta-cells in pancreatic islets, Pflügers Arch 351:195 (1974).PubMedCrossRefGoogle Scholar
  7. 7.
    H. P. Meissner and W. Schmeer, The significance of calcium ions for the glucose-induced electrical activity of pancreatic β-cells, in: “The Mechansims of Gatted Calcium Transport Across Biological Membranes”, Academic Press, Inc. , (1981).Google Scholar
  8. 8.
    M. Vasseur, A. Debuyser and M. Joffre, Sensibility of the pancreatic beta cells to calcium channel blockers. An electrophysiological study of Verapamil and Nifedipine (submitted to Pflugers Arch.).Google Scholar
  9. 9.
    C. B. Wollheim and G. W. G. Sharp, Regulation of insulin release by calcium, Physiol. Rev. 61:914 (1981).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. Vasseur
    • 1
  • A. Debuyser
    • 1
  • M. Joffre
    • 1
  1. 1.Physiologie Animale CNRS U. A. 290“Biomembranes” U. E. R. SciencesPoitiers CedesFrance

Personalised recommendations