Abstract
Ca influx through the β-cell membrane represents an important step in the triggering of glucose-induced insulin secretion. The way in which β-cells recognize the glucose concentration and subsequently regulate Ca2+ influx has been the focal point of much of the research in islet physiology over the last two decades. We have studied Ca-channel activity in the β-cell using high external potassium [K+]0 to depolarize the membrane.1 The analysis of the resulting membrane noise revealed that the conductance of a single channel was about 6 pS with a mean open time of about 20 msec at 0 mV.1 Thus, β-cell Ca-channels behave similarly to Ca-channels described in other cells.6
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References
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© 1986 Plenum Press, New York
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Joost, S., Atwater, I. (1986). Insulin Release and K+-Induced Depolarization in Mouse Pancreatic β-Cells. In: Atwater, I., Rojas, E., Soria, B. (eds) Biophysics of the Pancreatic β-Cell. Advances in Experimental Medicine and Biology, vol 211. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5314-0_13
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DOI: https://doi.org/10.1007/978-1-4684-5314-0_13
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