Molecular Machines and Energy Channelling

  • Frits Kamp
  • Hans V. Westerhoff
Part of the NATO ASI Series book series (NSSA, volume 127)


This Workshop deals with the phenomenon of channelling, being defined as the transfer of metabolites between enzymes before the former equilibrate with a pool. Several examples of channelling have been outlined. The question may be raised, whether also energy can be channelled from locations in the cell producing energy towards locations consuming energy. This question is of particular significance in the field of bioenergetics, studying mechanisms of free-energy transduction.


Energy Change Specific Degree Molecular Machine Activation Entropy Partial Molar Entropy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Albery, W.J. and Knowles, J.R., 1976, Biochemistry. 15: 5627.PubMedCrossRefGoogle Scholar
  2. Blumenfeld, L.A., 1983, “Physics of Bioenergetic Processes”, Springer-Verlag, Heidelberg.CrossRefGoogle Scholar
  3. Boyer, P.D., 1965, in: “Oxidases and Related Redox Systems”, Vol. 2, T. E. King, H. S. Mason, and M. Morrison, eds., Wiley, New York.Google Scholar
  4. Del Guidice, E., Doglia, A and Milani, M., 1982, Phys. Letters, 90A (1,2): 104.Google Scholar
  5. Fröhlich, H., 1982, Adv. Electron. Elect. Phys., 53: 85.CrossRefGoogle Scholar
  6. Glasstone, S., Laidler, K.J., and Eyring, H., 1941, “The Theory of Rate Processes”, McGraw-Hill, New York.Google Scholar
  7. Gray, B.F. and Gonda, I., 1977, J. Theor. Biol., 69: 167.PubMedCrossRefGoogle Scholar
  8. Hill, T.L., 1975, Prog, Biophyst Mol., Biol., 29: 149.Google Scholar
  9. Hill, T.L., 1977, “Free Energy Transduction in Biology”, Academic Press, New York.Google Scholar
  10. Hill, T.L. and Eisenberg, E., 1981, Quart. Rev. Biophys., 14: 463.CrossRefGoogle Scholar
  11. Kemeny, G., 1974, Proc. Natl. Acad. Sci. USA, 71: 2655.PubMedCrossRefGoogle Scholar
  12. King, E.L. and Altman, C., 1956, J. Phys. Chem., 60: 1375.CrossRefGoogle Scholar
  13. Malmstrom, B., 1985, Biochim. Biophys. Acta, 811: 1.PubMedGoogle Scholar
  14. McClare, C.W.F., 1970, J. Theor. Biol., 30: 1.CrossRefGoogle Scholar
  15. McClare, C.W.F., 1974, Ann. N. Y. Acad. Sci., 227: 74.PubMedCrossRefGoogle Scholar
  16. Nicolis, G. and Prigogine, L, 1977, “Self-Organization in Non-Equilibrium Systems”, Wiley, New York.Google Scholar
  17. Somogyi, B., Welch, G.R., and Damjanovich, S., 1984, Biochim. Biophys. Acta, 768: 81.PubMedGoogle Scholar
  18. van Dam, K. and Westerhoff, H.V., 1984, in: “Bioenergetics”, L. Ernster, ed., Elsevier, Amsterdam.Google Scholar
  19. Welch, G.R. and Berry, M.N., 1983, in: “Coherent Excitations in Biological Systems”, H. Fröhlich and F. Kremer, eds., Springer-Verlag, Heidelberg.Google Scholar
  20. Welch, G.R. and Kell, D.B., 1986, in: “The Fluctuating Enzyme”, G.R. Welch, ed., Wiley, New York.Google Scholar
  21. Welch, G.R., Somogyi, B., and Damjanovich, S., 1982, Prog. Biophys. Mol. Biol., 39: 109.PubMedCrossRefGoogle Scholar
  22. Westerhoff, H.V. and Chen, Y-D., 1985, Proc. Natl. Acad. Sci. USA, 82: 3222.PubMedCrossRefGoogle Scholar
  23. Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. and Kell, D.B., 1985, Biochim. Biophys. Acta, 768: 257Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Frits Kamp
    • 1
  • Hans V. Westerhoff
    • 1
  1. 1.National Institute of Digestive Metabolic and Kidney DiseasesNational Institutes of HealthBethesdaUSA

Personalised recommendations