Complex Patterns of Excitability and Oscillations in a Biochemical System
The organization of cell metabolism possesses spatial, functional, and temporal aspects; all these are closely intertwined. Spatial organization relates, for example, to the intracellular localization of biochemical processes, and to the manner in which enzymes that belong to a given pathway interact by forming multienzyme complexes. Functional organization is exemplified by the cellular response to hormonal and neural stimuli, through metabolic cascades of interconvertible enzymes controlled by intracellular messengers such as cyclic AMP. Temporal organization, on the other hand, encompasses the sequence of metabolic events along the cell cycle and their coordination according to growth and differentiation (obviously, spatial and functional organization are involved in such coordination).
KeywordsPhase Portrait Negative Slope Stable Limit Cycle Stable Steady State Temporal Organization
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