Functional and Structural Heterogeneity of the Inner Mitochondrial Membrane

  • Dieter Brdiczka
  • Albrecht Reith
Part of the NATO ASI Series book series (NSSA, volume 127)


The existence in mammalian cells of two ATP-providing systems, as well as DNA and protein synthesis, both inside and outside the mitochondrial compartment, implies sensitive control and regulation between the two compartments. Recent studies have revealed a complex organization at the mitochondrial periphery responsible for this regulation, in which the outer membrane pore, the enzymes in the peripheral mitochondrial compartment, and the peripheral part of the inner membrane (i.e., inner boundary membrane) are involved.


Cytochrome Oxidase Succinate Dehydrogenase Liver Mitochondrion Freeze Fracture Mitochondrial Compartment 
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  1. Allmann, D.W., Bachmann, E., Orme-Johnson, N., Tan, W.C., and Green, D.E., 1968, Arch Biohem Biophyg., 125:981.CrossRefGoogle Scholar
  2. Bessmann, S.P. and Carpenter, C.L., 1985, Ann. Rev. Biochem. 54:831.CrossRefGoogle Scholar
  3. Brdiczka, D., Dolken, G. Krebs, W. and Hofmann, D., 1974, Hoppe-Sevlers Physiol Chem., 355:731.CrossRefGoogle Scholar
  4. Brdiczka, D., Knoll, G., Riesinger, I., Weiler, U., Klug, G., Benz, R. and Krause, J., 1985, in: “Myocardial and Skeletal Muscle Bioenergetics”, N. Brautbar, ed., Plenum Press, New York.Google Scholar
  5. Deams, W.T. and Wisse, E., 1966 J. Ultrastruct, Res. 16:123.CrossRefGoogle Scholar
  6. Fernandez-Moran, H., 1962, Circulation, 26:1039.PubMedGoogle Scholar
  7. Fiek, Ch., Benz, R., Roos, N. and Brdiczka, D., 1982, Biochim. Biophys. Acta 688:429.PubMedCrossRefGoogle Scholar
  8. Fringes, B. and Reith, A., 1982, Lab. Invest., 47:19.PubMedGoogle Scholar
  9. Gots, R.E., and Bessman, S.P., 1974, Arch, Biochem Biophys, 163:7.CrossRefGoogle Scholar
  10. Hackenbrock, C.R., 1968, Proc. Natl. Acad. Sci. U.S.A. 61:598.PubMedCrossRefGoogle Scholar
  11. Hay, R., Bohni, P. and Gasser, S., 1984, Biochim, Biophys. Acta, 779:65.Google Scholar
  12. Inui, M. and Ishibashi, S., 1979, J. Biochem., 85:1151.PubMedGoogle Scholar
  13. Knoll, G. and Brdiczka, D., 1983, Biochim, Biophys. Acta, 733:102.CrossRefGoogle Scholar
  14. Loud, A.V., 1968, J. Cell Biol. 37:27.PubMedCrossRefGoogle Scholar
  15. Muscatello, U. and Carafoli, E., 1969, J. Cell Biol. 40:602.PubMedCrossRefGoogle Scholar
  16. Nolte, J. and Pette, D., 1971, in: “Recent Advances in Quantitative Histo- and Cytochemistry”, U.C. Durbach and U. Schmidt, eds., H. Huber, Bern.Google Scholar
  17. Palade, G.E., 1952, Anat. Record, 114:427.CrossRefGoogle Scholar
  18. Pilstrom, L. and Kiessling, K.H., 1972, Histochemie, 32:329.PubMedCrossRefGoogle Scholar
  19. Racker, E. and Kandrach, A., 1971, J. Biol. Chem., 246:7069.PubMedGoogle Scholar
  20. Reichmann, H., Hoppeler, H., Mathieu-Castello, O., Von Bergen, F. and Pette, D., 1985, Pflugerg Arch., 404:1.CrossRefGoogle Scholar
  21. Reith, A., 1972, Cytobiol., 5:384.Google Scholar
  22. Reith, A., 1977, Mikroskopie, 33:95.PubMedGoogle Scholar
  23. Reith, A., 1980, Gegenbaurs moroh. Jahrb., Leipzig, 126:327.Google Scholar
  24. Reith, A., Bardiczka, T. and Rohr, H.P., 1976, CRC Crit. Rev. Toxicol., 4:219.Google Scholar
  25. Reith, A., Brdiczka, D., Nolte, J. and Staudte, H.W., l973, Exptl. Cell Res., 77:1.CrossRefGoogle Scholar
  26. Schatz, G., 1979, FEBS Letters, 103:201.CrossRefGoogle Scholar
  27. van Venetie, R., and Verkleij, A.F., 1982, Biochim, Biophys. Acta, 692:379.Google Scholar
  28. Vazquez, H.J., Santiago, E., Guerra, F., and Maearulla, J.M., 1968, Rev. Espan, Fisiol., 24:43Google Scholar
  29. Vogell, W., 1965, Naturwissenschaften, 52:405.CrossRefGoogle Scholar
  30. Werner, S. and Neupert, W., 1972, Eur. J. Bioohem., 25:379.CrossRefGoogle Scholar
  31. Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. and Kell, D.B., 1984, FEBS Letters, 165:1PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Dieter Brdiczka
    • 1
  • Albrecht Reith
    • 2
  1. 1.Faculty of BiologyUniversity of KonstanzKonstanz 1Germany
  2. 2.Laboratory for Electron Microscopy and MorphometryThe Norwegian Radium Hospital and Institute for Cancer Research MontebelloOslo 3Norway

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