Enzyme Interactions in the Citric Acid Cycle and the Aspartate-Malate Shuttle

  • Sonia Beeckmans
  • Louis Kanarek
Part of the NATO ASI Series book series (NSSA, volume 127)


The citric acid cycle is central to energy metabolism in various types of cells, especially that of aerobic organisms. Incoming acetyl- units, which are provided by the degradation of sugars, fatty acids, or amino acids, are completely converted to CO2 and reducing equivalents. The latter are used for the production of ATP, by a process in which the flow of electrons through the consecutive complexes of the electron transport chain is coupled to the vectorial transport of protons. Since several citric acid cycle intermediates (e.g., oxaloacetate, α-keto- glutarate, succiny 1-CoA) are precursors of essential cell components, the cycle also has an important anabolic function. The cycle finds itself in the very peculiar situation whereby certain of its segments have potentially opposite functions, namely bioenergetic and biosynthetic.


Potassium Phosphate Malate Dehydrogenase Citric Acid Cycle Candida Utilis Malate Glutamate 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Sonia Beeckmans
    • 1
  • Louis Kanarek
    • 1
  1. 1.Laboratorium voor Chemie der ProteinenVrije Universiteit BrusselSint-Genesius-RodeBelgium

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