Enzyme Interactions in the Citric Acid Cycle and the Aspartate-Malate Shuttle
The citric acid cycle is central to energy metabolism in various types of cells, especially that of aerobic organisms. Incoming acetyl- units, which are provided by the degradation of sugars, fatty acids, or amino acids, are completely converted to CO2 and reducing equivalents. The latter are used for the production of ATP, by a process in which the flow of electrons through the consecutive complexes of the electron transport chain is coupled to the vectorial transport of protons. Since several citric acid cycle intermediates (e.g., oxaloacetate, α-keto- glutarate, succiny 1-CoA) are precursors of essential cell components, the cycle also has an important anabolic function. The cycle finds itself in the very peculiar situation whereby certain of its segments have potentially opposite functions, namely bioenergetic and biosynthetic.
KeywordsPotassium Phosphate Malate Dehydrogenase Citric Acid Cycle Candida Utilis Malate Glutamate
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- Brewer, G.J. and Sing, C.F., 1970, “An Introduction to Isozyme Techniques,” Academic Press, New York.Google Scholar
- Ernster, L. and Kuylenstierna, B., 1970, In: “Membranes of Mitochondria and Chloroplasts”, E. Racker, ed., Van Nostrand Reinhold, New York.Google Scholar
- Hayman, S., 1961, Ph.D. Thesis, University of Wisconsin.Google Scholar
- Srere, P.A., Halper, L.A., and Finkelstein, M.B., 1978, In: “Micro- environments and Metabolic Compartmentation”, P. A. Srere and R. Estabrook, eds., Academic Press, New York.Google Scholar