Some Aspects of Enzyme Organization in the Citric Acid Cycle

  • P. D. J. Weitzman
  • Sarah J. Barnes
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 127)


The citric acid (Krebs) cycle is a central metabolic pathway which occurs almost ubiquitously throughout Nature. Its basic two-fold function of providing energy and biosynthetic intermediates, together with its fundamental chemical unity across widely different organisms, have masked a remarkable diversity in the fine details of the enzymes of the cycle and of the regulatory mechanisms which may operate to control than. That diverse organisms may make different use of, or place different emphasis on, the separate functions of the cycle, and may therefore regulate the pathway in distinct ways, poses the possibility that organisms may differ in their organization of the enzymic apparatus of the cycle.


Succinate Dehydrogenase Malate Dehydrogenase Citric Acid Cycle Oxoglutarate Dehydrogenase Molecular Weight Peak 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. D. J. Weitzman
    • 1
  • Sarah J. Barnes
    • 1
  1. 1.Department of BiochemistryUniversity of BathBathEngland

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