Mitochondrial Hexokinase: Interactions between Glycolysis and Oxidative Phosphorylation

  • John E. Wilson
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 127)


In addition to its highly specific requirement for glucose as a substrate, the brain, unlike some other tissues, contains relatively little of the glucose storage form, glycogen. Thus the brain is critically dependent on a continued supply of blood-borne glucose and oxygen to maintain neurological function. This strict reliance on aerobic glucose metabolism is reflected in the organization of relevant enzymes in the brain.


Pyruvate Kinase Glycolytic Enzyme Mitochondrial Enzyme Adenylate Kinase Hexokinase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Felgner, P.L., Messer, J.L., and Wilson, J.E., 1979, J. Biol. Chem. 254:4946.PubMedGoogle Scholar
  2. Fiek, C., Benz, R., Roos, N. and Brdiczka, D., 1982, Biochim. Biophys. Acta, 688:429.PubMedCrossRefGoogle Scholar
  3. Johnson, M.K., 1960, Biochem. J., 77:610.PubMedGoogle Scholar
  4. Linden, M., Gellerfors, P., and Nelson, B.D., 1982, FEBS Lett. 141:189.PubMedCrossRefGoogle Scholar
  5. Lowry, O.H., Roberts, N.R., Schulz, D.W., Clow, J.E., and Clark, J.R., 1961, J. Biol. Chem., 236:2813.PubMedGoogle Scholar
  6. Pette, D., 1975, Acta Histochem. Supplementary Vol. 14, 47.Google Scholar
  7. Rose, I.A. and Warms, J.V.B., 1967, J. Biol. Chem. 242:1635.PubMedGoogle Scholar
  8. Staudte, H.W., and Pette, D., 1972, Comp. Biochem. Physiol., 41B:533.Google Scholar
  9. Wilson, J.E., 1972, J. Neurochem. 19:223.PubMedCrossRefGoogle Scholar
  10. Wilson, J.E., 1985, In: “Regulation of Carbohydrate Metabolism”, R. Beitner, ed., CRC Press, Boca Raton, FL.Google Scholar
  11. Wilson, J.E. and Feigner, P.L., 1977, Mol. Cell. Biochem., 18:39.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • John E. Wilson
    • 1
  1. 1.Biochemistry DepartmentMichigan State UniversityEast LansingUSA

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