Direct Transfer of Metabolites Via Enzyme-Enzyme Complexes: Evidence and Physiological Significance

  • S. A. Bernhard
  • D. K. Srivastava
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 127)


This paper deals with the transfer of metabolites (M) from one enzyme site (E1), the site of synthesis, to another enzyme site (E2), the site of utilization. Some such metabolite transfers have already been demonstrated to proceed by the direct interaction of a pair of enzymes involved in sequential steps of a metabolic pathway (Weber and Bernhard, 1982; Srivastava and Bernhard, 1984, 1985, 1986a, b). In such transfers the common metabolite is not exposed to an intermediate “solvent” environment. This direct transfer process is in contrast to the usually implicit model of metabolite transfer via dissociation from E1 and subsequent arrival at E2 via random diffusion through the aqueous environment (Eq. 1).


Direct Transfer Reaction Velocity Phosphoglycerate Mutase Intermediary Metabolite Common Metabolite 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • S. A. Bernhard
    • 1
  • D. K. Srivastava
    • 1
  1. 1.Institute of Molecular BiologyUniversity of OregonEugeneUSA

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