Abstract
A metabolite being released from the active site of an enzyme may find itself in the predicament of deciding which pathway to choose among several possibilities. For instance, once glucose-6-P has been synthesized several alternative paths are possible, e.g., glycogen synthesis via phosphoglucomutase, glycolysis via phosphoglucose- isomerase, pentose-P pathway via glucose-6-P dehydrogenase, or back again to glucose through glucose-6-phosphatase (Fig. 1). Furthermore, the same situation will happen again at every branch-point along the metabolic maze until a committed step is reached.
“Adso,“William said, ”solving a mystery is not the same as deducing from first principles. Nor does it amount simply to collecting a number of particular data from which to infer a general law. It means, rather, facing one or two or three particular data apparently with nothing in common, and trying to imagine whether they could represent so many instances of a general law you don’t yet know, and which perhaps has never been pronounced.”…
… “And this is what I am doing now. I line up so many disjointed elements and I venture some hypotheses. I have to venture many, and many of them are so absurd that I would be ashamed to tell them to you.”
(Umberto Eco, The Name of the Rose, Fourth Day, Vespers)
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© 1986 Plenum Press, New York
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Ureta, T., Radojković, J. (1986). Organization of Glucose Metabolism: A Model of Compartments by Poly-Isozymic Complexes. In: Welch, G.R., Clegg, J.S. (eds) The Organization of Cell Metabolism. NATO ASI Series, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5311-9_13
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