Advertisement

Cytochrome Oxidase in Energy Transduction

  • M. Brunori
  • P. Sarti
  • G. Antonini
  • F. Malatesta
  • M. T. Wilson

Summary

Cytochrome-c-oxidase, an integral membrane protein of the inner mitrochondrial membrane, is the terminal enzyme of the respiratory chain. This paper summarizes the role of this enzyme in energy conservation, and presents a possible regulatory model based on ΔμH+ linked conformational changes of the macromolecule.

Keywords

Cytochrome Oxidase Mobile Element Electrochemical Gradient Phospholipid Vesicle Energy Transduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R. Henderson and P.N.T. Unwin, Nature, 257, 28 (1975).PubMedCrossRefGoogle Scholar
  2. 2.
    J.F. Deatherage, R. Henderson and R.A. Capaldi, J. Mol. Biol., 158, 487 (1982).PubMedCrossRefGoogle Scholar
  3. 3.
    J. Deisenhofer, O. Epp, K. Miki, R. Huber and H. Michel, J. Mol. Biol., 180, 385 (1984).PubMedCrossRefGoogle Scholar
  4. 4.
    R.A. Capaldi, F. Malatesta and V. Darley-Usmar, Biochim. Biophys. Acta, 726, 135 (1983).PubMedGoogle Scholar
  5. 5.
    M. Wikström, K. Krab and M. Saraste, “Cythochrome oxidase. A synthesis,” Academic Press (1981).Google Scholar
  6. 6.
    M. Brunori and M.T. Wilson, Trends Biochem. Sci., 7, 295 (1982).CrossRefGoogle Scholar
  7. 7.
    A. Azzi, Biochim. Biophis. Acta, 594, 231 (1980).Google Scholar
  8. 8.
    S.B. Vik, G. Georgevich and R.A. Capaldi, Proc. Nat. Acad. Sci., 78, 1456 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    P. Mitchell, Biol. Rev., 41, 445 (1966).PubMedCrossRefGoogle Scholar
  10. 10.
    D.G. Nichols, “Bioenergetics,” Academic Press, London (1982).Google Scholar
  11. 11.
    J. Wyman, Acad. Naz. Lincei, Ser VIII, 64, 409 (1978).Google Scholar
  12. 12.
    T.L. Hill, Trends Biochem. Sci., 2, 204 (1977).CrossRefGoogle Scholar
  13. 13.
    J. Wyman, Adv. Protein Chem., 19, 223 (1964).PubMedCrossRefGoogle Scholar
  14. 14.
    M. Brunori, M. Coletta, B. Giardina and J. Wyman, Proc. Nat. Acad. Sci., 75, 4310 (1978).PubMedCrossRefGoogle Scholar
  15. 15.
    E. Antonini and M. Brunori, “Hemoglobin and Myoglobin in their reactions with ligands,” North Holland, Amsterdam, 21 (1971).Google Scholar
  16. 16.
    M.F. Perutz, Nature, 228, 726 (1970).PubMedCrossRefGoogle Scholar
  17. 17.
    J. Monod, J. Wyman and J.P. Changeux, J. Mol. Biol., 12, 88 (1965).PubMedCrossRefGoogle Scholar
  18. 18.
    M. Wikström, Nature, 266, 271 (1977).PubMedCrossRefGoogle Scholar
  19. 19.
    E. Sigel and E. Carafoli, Eur. J. Biochem., 89, 119 (1978).PubMedCrossRefGoogle Scholar
  20. 20.
    R.P. Casey, M. Thelen and A. Azzi, J. Biol. Chem., 255, 3994 (1980).PubMedGoogle Scholar
  21. 21.
    P. Hinkle, J.J. Kim and E. Racker, J. Biol. Chem., 247, 1338 (1979).Google Scholar
  22. 22.
    J.M. Wrigglesworth, Proc. FEBS Meet. 11th, 45, 95 (1978).Google Scholar
  23. 23.
    P. Sarti, A. Colosimo, M. Brunori, M.T. Wilson and E. Antonini, Biochem. J., 209, 81 (1983).PubMedGoogle Scholar
  24. 24.
    P. Sarti, M.G. Jones, G. Antonini, F. Malatesta, A. Colosimo, M.T. Wilson and M. Brunori, Proc. Nat. Acad. Sci., 82, 4876 (1985).PubMedCrossRefGoogle Scholar
  25. 25.
    M. Brunori, P. Sarti, A. Colosimo, G. Antonini, F. Malatesta, M.G. Jones and M.T. Wilson, EMBO J., 4, 2365 (1985).PubMedGoogle Scholar
  26. 26.
    M.T. Wilson, J. Peterson, E. Antonini, M. Brunori, A. Colosimo and J. Wyman, Proc. Nat. Acad. Sci., 78, 7115 (1981).PubMedCrossRefGoogle Scholar
  27. 27.
    D. Pietrobon, G.F. Azzone and D. Walz, Eur. J. Biochem., 117, 389 (1981).PubMedCrossRefGoogle Scholar
  28. 28.
    J.M. Wrigglesworth, J. Inorg. Biochem., 23, 311 (1985).PubMedCrossRefGoogle Scholar
  29. 29.
    M. Müller and A. Azzi, J. Bioenerg. Biomembranes, 17, 385 (1985).CrossRefGoogle Scholar
  30. 30.
    Manuscript in preparation.Google Scholar
  31. 31.
    A.L. Hodgkin and A.F. Huxley, J. Physiol., 117, 500 (1952).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. Brunori
    • 1
    • 4
  • P. Sarti
    • 1
  • G. Antonini
    • 1
  • F. Malatesta
    • 2
  • M. T. Wilson
    • 3
  1. 1.Dept. of Biochemical Sciences and CNR Center of Molecular BiologyUniversity of Rome La SapienzaRomeItaly
  2. 2.Dept. of Experimental Medicine and Biochemical SciencesUniversity of Rome Tor VergataRomeItaly
  3. 3.Dept. of ChemistryUniversity of EssexColchesterUK
  4. 4.F.I.C., N.I.H.BethesdaUSA

Personalised recommendations