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Purification of a Survival Factor for Spinal Neurons from Mouse Salivary Gland

  • M. E. Gurney
  • B. R. Apatoff
  • S. P. Heinrich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)

Abstract

A variety of factors influence neuronal survival and differentiation in culture systems. Since neurons are post-mitotic with only rare exceptions, neurons are not acted upon by mitogens. The factors which have been described to date divide naturally into three categories: factors which influence survival in culture, factors which influence substrate attachment and neurite outgrowth, and factors which influence biochemical differentiation[1]. The biological role in vivo of only one, NGF (nerve growth factor), has received experimental support[2].

Keywords

Amyotrophic Lateral Sclerosis Salivary Gland Nerve Growth Factor Motor Neuron Survival Spinal Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. E. Gurney
    • 1
  • B. R. Apatoff
    • 1
  • S. P. Heinrich
    • 1
  1. 1.Dept. of Pharmacological and Physiological SciencesThe University of ChicagoChicagoUSA

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