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Motor Neuron Disease: Epidemiologic Studies

  • D. W. Mulder
  • L. T. Kurland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)

Summary

The etiology of motor neuron disease (MND) is unknown and treatment is limited to measures which sustain the patient. We review selected epidemiologic studies searching for a pattern in the clinical expression of MND which may reflect the operation of the underlying cause. Recognition of patterns of occurrence of MND might provide the basis for testable etiologic hypotheses for MND. In addition, recognition of the association of MND with diseases of known cause or the analogy of diseases of known cause with MND may provide further etiologic hypotheses.

Keywords

Amyotrophic Lateral Sclerosis Muscular Atrophy Motor Neuron Disease Motor Neuron Disease Familial Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    D. Goldblatt, Motor neuron disease: historical introduction, in: “Motor Neuron Diseases: Research on Amyotrophic Lateral Sclerosis and Related Disorders,” F. H. Norris and L. T. Kurland, eds., Grune and Stratton, New York, p. 3 (1969).Google Scholar
  2. 2.
    S. M. Juergens, L. T. Kurland, H. Okazaki, and D. W. Mulder, Amyotrophic lateral sclerosis in Rochester, Minnesota, 1925-77, Neurol., 30: 463–470 (1980).CrossRefGoogle Scholar
  3. 3.
    D. W. Mulder and F. M. Howard, Patient resistance and prognosis in amyotrophic lateral sclerosis, Mayo Clin.Proc., 51: 537–541 (1976).PubMedGoogle Scholar
  4. 4.
    D. W. Mulder, The clinical syndrome of ALS, Proc.Staff Meeting Mayo Clinic, 32: 427–436 (1957).Google Scholar
  5. 5.
    S. Hansen and J. P. Ballantyne, A quantitative electrophysiologic study of motor neuron disease, J.Neurol.Neurosurg.Psych., 41: 773 (1978).CrossRefGoogle Scholar
  6. 6.
    D. W. Mulder, L. T. Kurland, K. P. Offord, and C. M. Beard, Familial adult motor neuron disease, Neurol., 36:511–517 (1986) (in press).Google Scholar
  7. 7.
    D. W. Mulder, E. H. Lambert, and L. M. Eaton, Myasthenia syndrome in patients with ALS, Neurol., 9: 627–631 (1959).CrossRefGoogle Scholar
  8. 8.
    D. W. Mulder, W. Bushek, E. Spring, J. Harnes, and P. J. Dyck, Motor neuron disease: evaluation of detection thresholds of cutaneous sensation, Neurol., 33: 1625–1627 (1983).CrossRefGoogle Scholar
  9. 9.
    E. H. Lambert, Electromography in ALS, in: “Motor Neuron Disease,” F. H. Norris and L. T. Kurland, eds., Grune and Stratton, New York, pp. 135–154 (1969).Google Scholar
  10. 10.
    B. Morris, Muscle biopsy, in: “The Diagnosis and Treatment of Amyotrophic Lateral Sclerosis,” D. W. Mulder, ed., John Wiley & Sons, pp. 119–129 (1980).Google Scholar
  11. 11.
    L. T. Kurland and D. W. Mulder, Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution, with special reference to the Mariana Islands, including clinical and pathologic observations, Neurol., 4: 355–438 (1954).CrossRefGoogle Scholar
  12. 12.
    R. E. Espinosa, M. M. Okihiro, D. W. Mulder, and Sayre, G.P. Hereditary amyotrophic lateral sclerosis. A clinical and pathologic report with comments on classification, Neurol., 12: 1–7 (1962).CrossRefGoogle Scholar
  13. 13.
    L. T. Kurland and D. W. Mulder, Epidemiologic investigations of amyotrophic lateral sclerosis. II. Familial aggregations indicative of dominant inheritance, Neurol., 5: 182–268 (1955).CrossRefGoogle Scholar
  14. 14.
    K. Kumura, et al. (Depts. Neuropsychiat. & Anat. Wakayama Medical College, Wakayama). Endemiological and geomedical studies on amyotrophic lateral sclerosis and allied diseases in Kii Peninsula, Japan (Preliminary Report), Folia Psychiat.Neurol.Jap., 15: 175–181 (1961).Google Scholar
  15. 15.
    D. C. Gadjusek and A. M. Salazar, Amyotrophic lateral sclerosis and parkinsonian syndromes among the Auyu and Jakai people of West New Guinea, Neurol., 32: 107–126 (1982).CrossRefGoogle Scholar
  16. 16.
    L. Chen, Neurofibrillary change on Guam, Arch.Neurol., 38: 16 (1981).PubMedCrossRefGoogle Scholar
  17. 17.
    F. A. Aran, Recherches sur une maladie non encore decrite du systeme musculaire (atrophie musculaire progressive), Arch.Gen.Med., 24: 5 (1850).Google Scholar
  18. 18.
    R. Pierce-Ruhland and B. M. Patten, Repeat study of antecedent events in motor neuron disease, Ann.Clin.Res., 13: 102–107 (1981).PubMedGoogle Scholar
  19. 19.
    S. Conradi, L. 0. Ronnevi, G. Nise, and O. Vesterberg, Long-time penicillamine-treatment in amyotrophic lateral sclerosis with parallel determination of lead in blood, plasma and urine, Acta.Neurol.Scand., 65: 203–211 (1982).Google Scholar
  20. 20.
    R. Roelofs-Iverson, D. W. Mulder, L. R. Elveback, L. T. Kurland, and C. A. Molgaard, ALS and heavy metals: a pilot case-control study, Neurol., 34: 393–5 (1984).CrossRefGoogle Scholar
  21. 21.
    K. Kondo and T. Tsubaki, Case-control studies of motor neuron disease. Association with mechanical injuries, Arch.Neurol., 38: 220–226 (1981).PubMedCrossRefGoogle Scholar
  22. 22.
    R. Garruto, R. Yanagihara, and D. C. Gadjusek, Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam, Neurol., 35: 193–198 (1985).CrossRefGoogle Scholar
  23. 23.
    L. T. Kurland and D. W. Mulder, Overview of motor neuron disease, Symp. on Motor Neuron Disease, Bangalore, India, October 29 (1984).Google Scholar
  24. 24.
    L. P. Rowland, Molecular genetics, pseudogenetics, and clinical neurology, Neurol., 33: 1179–1193 (1983).CrossRefGoogle Scholar
  25. 25.
    V. A. McKusick, Diseases of the genome, J.Am.Med.Assoc., 252: 1041–8 (1984).CrossRefGoogle Scholar
  26. 26.
    P. Pinelli and E. Ramelli, Paralisi periferica controlaterale nomitica in paxients con postericur di poliomyelite (nel quadra del problema della paralisi tardive dei poliomielitiei), Riv.Sper.Freniat., 19: 1101–6 (1964).Google Scholar
  27. 27.
    M. B. Codd, D. W. Mulder, L. T. Kurland, C. M. Beard, and W. M. O’Fallon, Poliomyelitis in Rochester, Minnesota, 1935-1955: epidemiology and long-term sequelae: a preliminary report, in: “Late Effects of Poliomyelitis,” L. S. Halstead and D. O. Wiechers, eds. Symposia Foundation, Florida, pp. 121–34 (1985).Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • D. W. Mulder
    • 1
  • L. T. Kurland
    • 2
  1. 1.Department of NeurologyRochesterUSA
  2. 2.Department of Medical Statistics and EpidemiologyMayo Clinic and Mayo FoundationRochesterUSA

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