A Therapeutic Trial of a Thymic Factor in Amyotrophic Lateral Sclerosis (ALS)

  • L. Provinciali
  • A. R. Giovagnoli
  • P. Di Bella
  • M. Baroni
  • R. Dellantonio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)


Previous studies supported the hypothesis that some immunological abnormalities might be involved in the pathogenesis of ALS. On this basis some therapeutic trials have been attempted with various immunomodulating agents such as isoprinosine[1,2] levamisole[3], transfer factor[4] and interferon[5]. Other therapeutic trials, which have been based on the assumption that ALS may be considered an autoimmune disease, have used immunosuppressor drugs such as azathiopurine, methotrexate and cytotosine-arabinoside[6]. No significant results were described in any of these studies.


Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Patient Therapeutic Trial Transfer Factor Motor Neuron Disease 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • L. Provinciali
    • 1
  • A. R. Giovagnoli
    • 1
  • P. Di Bella
    • 1
  • M. Baroni
    • 1
  • R. Dellantonio
    • 1
  1. 1.Instituto delle Malattie del Sistema NervosoUniversity of AnconaItaly

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