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Attempted Treatment of Motor Neuron Disease with N-Acetylcysteine and Dithiothreitol

  • J. M. B. V. de Jong
  • W. A. den Hartog Jager
  • A. Vyth
  • J. G. Timmer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)

Abstract

N-acetylcysteine (NAC) and Dithiothreitol (DTT), two compounds that prevent experimental amyotrophic lateral sclerosis (ALS) in the vitamin C - deficient guinea pig[1], were given to patients with motor neuron disease (MND). These patients were accepted regardless of the stage of their illness, promised uninterrupted treatment, instructed to come for monthly out-patient visits, forbidden the use of the NAC-antagonists phenacetin and acetaminophen and left free to continue any other mode of attempted therapy.

Keywords

Amyotrophic Lateral Sclerosis Spinal Muscular Atrophy Motor Neuron Disease Motor Neuron Disease Stretch Reflex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W. A. den Hartog Jager, Experimental amyotrophic lateral sclerosis in the guinea pig, J.Neurol.Sci., 67: 133–142 (1985).CrossRefGoogle Scholar
  2. 2.
    F. H. Norris, Jr., P. R. Calanchini, R. J. Fallat, S. Panchari, and B. Jewett, The administration of guanidine in amyotrophic lateral sclerosis, Neurology (Minneap.), 24: 721–8 (1974).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. M. B. V. de Jong
    • 1
  • W. A. den Hartog Jager
    • 1
  • A. Vyth
    • 2
  • J. G. Timmer
    • 2
  1. 1.Dept. of NeurologyAcademic Medical Centre at the University of AmsterdamAmsterdamthe Netherlands
  2. 2.Dept. of PharmacyAcademic Medical Centre at the University of AmsterdamAmsterdamthe Netherlands

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