A Study of Prognostic Factors in Motor Neuron Disease
Latest advances in the study of motor neuron disease (MND) have pointed out some differences in the course of the illness; subgroups of patients with different survival experience have been identified. A review of studies based on survival analysis is reported in Table 1. It shows the 5-year survival variable from 10 to 50%. Few reports have been devoted to an extensive study of prognostic factors in MND[2, 14, 20, 23]. Age and clinical type at diagnosis are generally considered to influence the course of the disease.
KeywordsAmyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Patient Motor Neuron Disease Motor Neuron Disease Clinical Type
Unable to display preview. Download preview PDF.
- 2.J. T. Caroscio, W. F. Calhoum, and N. D. Yahr, Prognostic factors in motor neuron disease: a prospective study of longevity, in: F. Clifford Rose, ed., “Research Progress in Motor Neuron Disease,” Pitman, London, pp. 34–43 (1984).Google Scholar
- 3.A. Chió, F. Brignolio, M. Leone, P. Mortara, M. G. Rosso, A. Tribolo, and D. Schiffer, A survival analysis of 155 cases of progressive muscular atrophy, Acta Neurol.Scand., 72: 401–413 (1985).Google Scholar
- 5.W. D. Dixon, M. B. Brown, L. Engleman, J. W. Frane, M. A. Hill, R. I. Jennrich, and J. D. Toporek, eds., “BMDP Statistical Software,” University of California Press, Los Angeles (1983).Google Scholar
- 9.C. H. Hawkes, J. B. Cavanagh, S. Mowbray, and E. A. Paul, Familial motor neuron disease: report of a family with 5 post-mortem studies, in: “Research Progress in Motor Neuron Disease,” F. Clifford Rose, ed., Pitman, London, pp. 70–98 (1984).Google Scholar
- 15.D. W. Mulder, R. A. Rosenbaum, and D. Layton, Jr., Late progression of poliomyelitis or forme fruste amyotrophic lateral sclerosis? Mayo Clinic Proc., 47: 756–761 (1972).Google Scholar
- 16.D. W. Mulder and F. M. Howard Jr., Patient resistance and prognosis in amyotrophic lateral sclerosis, Mayo Clinic Proc., 51: 537–541 (1976).Google Scholar
- 18.F. H. Norris, Adult spinal motor neuron disease, in: “Handbook of Clinical Neurology,” P. J. Vinken and G. W. Bruyn, eds., vol.22, System Disorders and Atrophy, North-Holland, Amsterdam, pp. 1–56.Google Scholar
- 19.R. Peto, M. C. Pike, P. Armitage, N. E. Breslow, D. R. Cox, S. V. Howard, N. Mantel, K. MacPherson, J. Peto, and P. G. Smith, Design and analysis of randomized clinical trials requiring prolonged observation of each patient analysis and example, Brit.J.Cancer, 35: 1–39 (1977).PubMedCrossRefGoogle Scholar
- 21.SAS user’s guide: basics, SAS Institute Inc., Cary, N.C. (1982).Google Scholar