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Immunological Assessment in Sporadic Amyotrophic Lateral Sclerosis (ALS)

  • L. Provinciali
  • A. R. Giovagnoli
  • S. Battucci
  • C. Bartocci
  • M. Montroni
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)

Abstract

The immune system may be able to contribute to the pathogenesis of ALS as it has to other neurological diseases such as experimental allergic encephalomyelitis, multiple sclerosis and lymphocytic choriomeningitis. The selective damage to upper and lower motor neurons in ALS might be regarded as a feature of a brain-confined, organ-specific autoimmune disease. The greater frequency of some histocompatibility antigens (HLA3, HLB12, HLBW35) may suggest the possible predisposition to autoimmune and infectious diseases [1-3].

Keywords

Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Patient Motor Neuron Disease Experimental Allergic Encephalomyelitis Lower Motor Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • L. Provinciali
    • 1
  • A. R. Giovagnoli
    • 1
  • S. Battucci
    • 2
  • C. Bartocci
    • 2
  • M. Montroni
    • 2
  1. 1.Instituto delle Malattie del Sistema NervosoItaly
  2. 2.Istituto di Patologia Speciale MedicaMetodologia Clinica University of AnconaItaly

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