Immunological Assessment in Sporadic Amyotrophic Lateral Sclerosis (ALS)
The immune system may be able to contribute to the pathogenesis of ALS as it has to other neurological diseases such as experimental allergic encephalomyelitis, multiple sclerosis and lymphocytic choriomeningitis. The selective damage to upper and lower motor neurons in ALS might be regarded as a feature of a brain-confined, organ-specific autoimmune disease. The greater frequency of some histocompatibility antigens (HLA3, HLB12, HLBW35) may suggest the possible predisposition to autoimmune and infectious diseases [1-3].
KeywordsAmyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Patient Motor Neuron Disease Experimental Allergic Encephalomyelitis Lower Motor Neuron
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