Spinal Cord Electrophysiological Activities After Small Doses of TRH in Control Subjects and ALS Patients

  • P. J. Delwaide
  • J. Schoenen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)


Terminals containing TRH [1] as well as TRH receptors[2] have been identified in the ventral horn and intermediate gray matter of the human spinal cord. Their physiological role remains unknown. However, motor effects have been documented clinically after infusion of large amounts (up to 20 mg per minute) of TRH in ALS patients [3]. It is thus of interest to know if this neuropeptide is able to influence the motor system in normal man and, if so, which spinal mechanisms are involved. To study this problem, electrophysiological techniques are available which test the functioning of specific spinal circuits quantitatively. If the product acts on spinal circuits in normal subjects, another relevant question would be to establish if these modifications are the same in patients with spinal cord dysfunctions, namely in ALS. We therefore undertook a study in control subjects and compared the results with those obtained in neurological patients.


Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Patient Thyrotropin Release Hormone Motor Neurone Human Spinal Cord 


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  1. 1.
    J. Schoenen and P. J. Delwaide, TRH and F waves in ALS: differences between sporadic and familial forms, Neurology, 35 (1): 4–70 (1985).Google Scholar
  2. 2.
    S. Manaker, A, Winokur, C. H. Rhodes, and T. C. Rainbow, Autoradiographic localization of thyrotropin releasing hormone (TRH) receptors in human spinal cord, Neurology, 35: 328–332 (1985).Google Scholar
  3. 3.
    W. K. Engel, T. Siddique, and J. T. Nicoloff, Effect on weakness and spasticity in amyotrophic lateral sclerosis of thyrotropin- releasing hormone, Lancet, 2: 73–75 (1983).PubMedCrossRefGoogle Scholar
  4. 4.
    P. J. Delwaide, Electrophysiological testing of spastic patients, its potential usefulness and limitations, in: “Clinical Neurophysiology in Spasticity,” P. J. Delwaide and R. R. Young, eds., Restorative Neurology, Elsevier, Amsterdam 1:185–203, (1985).Google Scholar
  5. 5.
    P. J. Delwaide, J. Schoenen, and V. Dubois, Thyrotropin releasing hormone (TRH) increases excitability of human motor neurons as tested by the F waves, Neurology, 34: 284, 331 (1984).Google Scholar
  6. 6.
    P. J. Delwaide and J. Schoenen, The effects of TRH on F waves recorded from antagonistic muscles in human subjects, Ann.Neurol., 18: 366–367 (1985).PubMedCrossRefGoogle Scholar
  7. 7.
    P. J. Delwaide and J. Schoenen, TRH inhibits flexor reflexes in man, Neuology, 35 (1): 4–71 (1985).Google Scholar
  8. 8.
    J. Schoenen, M. Reznik, P. J. Delwaide, and J. J. Vanderhaeghen, Etude immunocytochimique de la distribution spinale de substance P, des enképhalines, de cholécystokinine et de sérotonine dans la sclérose latérale amyotrophique, C.R.Soc.Biol., 179: 528 - 534 (1985).Google Scholar
  9. 9.
    E. Pierrot-Deseilligny, W. K. Engel, and M. Fardeau, Effect of high- dose TRH (HD-TRH) on H reflex vibratory inhibition and H-reflex threshold in amyotrophic lateral sclerosis (ALS) patients, Neurology, 35 (1): 128 (1985).Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • P. J. Delwaide
    • 1
  • J. Schoenen
    • 1
  1. 1.Section of Neurology and Clinical NeurophysiologyUniversity of Liege, Hôpital de BaviereLiegeBelgium

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