Immunoglobulin-Mediated Cytotoxic Effect of ALS-Plasma Towards Erythrocytes: Reflexion of a Pathogenetic Mechanism?

  • S. Conradi
  • L.-O. Ronnevi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)


Degeneration of lower motor neurons in the spinal cord and brain stem is a main phenomenon in ALS. These motor neurons occupy a remarkable position in that their cell bodies and dendrites are located within the central neurous system, whereas their axons constitute part of the peripheral nerves. The distal endings of the motor neurons in the motor end plates are unprotected by the blood-brain and blood-nerve barriers, and are therefore directly exposed to various substances in the blood.


Amyotrophic Lateral Sclerosis Motor Neuron Amyotrophic Lateral Sclerosis Patient Motor Neuron Disease Control Plasma 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. Conradi
    • 1
  • L.-O. Ronnevi
    • 1
  1. 1.Department of NeurologyKarolinska SjukhusetStockholmSweden

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