Immunoglobulin-Mediated Cytotoxic Effect of ALS-Plasma Towards Erythrocytes: Reflexion of a Pathogenetic Mechanism?
Degeneration of lower motor neurons in the spinal cord and brain stem is a main phenomenon in ALS. These motor neurons occupy a remarkable position in that their cell bodies and dendrites are located within the central neurous system, whereas their axons constitute part of the peripheral nerves. The distal endings of the motor neurons in the motor end plates are unprotected by the blood-brain and blood-nerve barriers, and are therefore directly exposed to various substances in the blood.
KeywordsAmyotrophic Lateral Sclerosis Motor Neuron Amyotrophic Lateral Sclerosis Patient Motor Neuron Disease Control Plasma
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