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Light and Ultrastructural Studies in Sural Biopsies of the Pseudopolyneuropathic form of ALS

  • G. Di Trapani
  • P. David
  • A. La Cara
  • P. Tonali
  • P. Laurienzo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)

Abstract

Amyotrophic lateral sclerosis (ALS) is usually accepted as a disease in which degeneration of the first and second motor neuron is not accompanied by a sensory abnormality. Neuropathological studies on the sural nerve[l-4], and on deep and superficial peroneal nerves[5] of ALS patients have suggested that the primary sensory neuron may also be involved in this disease. We have studied the biopsy of the sural nerve using light and ultrastructural investigation in patients with the pseudopolyneuritic form of ALS. The aim of our work was to verify primary sensory neuron involvement in this particular form of ALS in order to single out an eventual pathogenetic mechanism.

Keywords

Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Patient Sural Nerve Motor Neuron Disease Myelinated Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • G. Di Trapani
    • 1
    • 2
  • P. David
    • 1
  • A. La Cara
    • 1
  • P. Tonali
    • 1
  • P. Laurienzo
    • 1
  1. 1.Institute of NeurologyCatholic UniversityRomeItaly
  2. 2.Institute of NeurologyCatholic UniversityRomeItaly

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