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Cytotoxicity of Serum from Amyotrophic Lateral Sclerosis Patients on Spinal Cord Cells in Culture

  • I. Maher
  • A. Pouplard-Barthelaix
  • J. Emile
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)

Abstract

The etiology and pathogenesis of amyotrophic lateral sclerosis are still in debate. Among various hypotheses from different laboratories, some in vitro studies have discussed the possibility of the presence of a deleterious factor (or factors) in the serum of ALS patients against cultured spinal cord explants[1-3]. Other workers could not confirm such findings[4-6]. The potential significance of such a possibility and the discrepancy between the results of these studies have motivated us to address the same question, with some difference in the employed techniques as described below.

Keywords

Amyotrophic Lateral Sclerosis Growth Cone Amyotrophic Lateral Sclerosis Patient Normal Human Serum Spinal Cord Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    F. Wolfgram and L. Meyers, Trans.Am.Neurol.Assoc., 97: 19–23 (1972).Google Scholar
  2. 2.
    F. Wolfgram and L. Meyers, Science, 179: 579–580 (1973).PubMedCrossRefGoogle Scholar
  3. 3.
    F. Roisen, H. Bartfeld, H. Donnefeld, and J. Baxter, Muscle and Nerve, 5: 48–53 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    M. Howrich, K. Engel, and B. Chauvin, Acta Neuropath., 32: 127–131 (1974).Google Scholar
  5. 5.
    J. Liveson, H. Frey, and M. Bornstein, Acta Neuropath., 32: 127–131 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    J. R. Lehrich and J. Lacouture, Ann.Neurol., 41: 384–385 (1978).CrossRefGoogle Scholar
  7. 7.
    B. Festoff, Med.Hypoth., 6: 121–132 (1980).CrossRefGoogle Scholar
  8. 8.
    J. B. Cavanaugh, Int.Rev.Exp.Path., 3: 219–267 (1966).Google Scholar
  9. 9.
    A. Oldstone, B. Wilson, D. Dalessio, F. Norris, and E. Nelson, Trans. Am.Neurol.Assoc., 98: 31–32 (1973).Google Scholar
  10. 10.
    G. Wohlfart, Neurology, 7: 124–130 (1957).PubMedCrossRefGoogle Scholar
  11. 11.
    A. Hirano and M. Iwata, in: “Proc. Int. Symp.”, Tsubaki and Toyokura, eds., Univ. Tokyo Press (1979).Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • I. Maher
    • 1
  • A. Pouplard-Barthelaix
    • 1
  • J. Emile
    • 1
  1. 1.Unité de Neuro-ImmunologieFaculté de MédecineAngersFrance

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