Cytotoxicity of Serum from Amyotrophic Lateral Sclerosis Patients on Spinal Cord Cells in Culture

  • I. Maher
  • A. Pouplard-Barthelaix
  • J. Emile
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 209)


The etiology and pathogenesis of amyotrophic lateral sclerosis are still in debate. Among various hypotheses from different laboratories, some in vitro studies have discussed the possibility of the presence of a deleterious factor (or factors) in the serum of ALS patients against cultured spinal cord explants[1-3]. Other workers could not confirm such findings[4-6]. The potential significance of such a possibility and the discrepancy between the results of these studies have motivated us to address the same question, with some difference in the employed techniques as described below.


Amyotrophic Lateral Sclerosis Growth Cone Amyotrophic Lateral Sclerosis Patient Normal Human Serum Spinal Cord Neuron 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • I. Maher
    • 1
  • A. Pouplard-Barthelaix
    • 1
  • J. Emile
    • 1
  1. 1.Unité de Neuro-ImmunologieFaculté de MédecineAngersFrance

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