The Effects of Two Dietary Fats on Hepatic VLDL Secretion and Composition in the Rhesus Monkey
Diets enriched in fat and cholesterol have been shown to produce marked elevations in plasma lipid levels and to increase the plasma apolipoprotein B content in the rhesus monkey (Armstrong, 1976). The nature of the fat fed along with the cholesterol influences the likelihood of the development of atherosclerosis. Peanut oil is an unsaturated vegtable oil that is notably atherogenic (Vesselinovitch et al., 1980), whereas lard is a more saturated atherogenic animal fat. Here we report the results of a study aimed at defining the specific contribution of the liver to the elevated lipid and apolipoprotein B content of plasma observed in animals fed diets rich in fat and cholesterol. In addition the effect of the various fats on liver production of apo A-I and apo E was assayed.
KeywordsRhesus Monkey Cholesteryl Ester Diet Group Cholesterol Diet Chow Group
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