An Overview of Lipoprotein Metabolism
Each of the conventionally defined lipoprotein classes in human plasma can be divided into particle subpopulations differing in their lipid and apoprotein content. Such structural heterogeneity generates diversity in the function and metabolic potential of the particles whose clinical significance has recently been emphasised in a number of kinetic studies. The present short overview highlights current developments in this area.
KeywordsHigh Density Lipoprotein Lipoprotein Metabolism Familial Hypercholesterolemia High Density Lipoprotein Particle Large VLDL
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- Alaupovic, P., 1984, The physicochemical and immunological heterogeneity of human plasma high density lipoproteins, in: Clinical and Metabolic Aspects of High Density Lipoproteins (N. E. Miller and G. J. Miller, eds.), Elsevier, Amsterdam, pp. 1–46.Google Scholar
- Atmeh, R. F., Shepherd, J., and Packard, C. J., 1983, Subpopulations of apolipoprotein AI in human high density lipoproteins: Their metabolic properties and response to drug therapy, Biochim. Bio -phys. Acta 751:175–188.Google Scholar
- Berman, M., Hall, M., Levy, R. I., Eisenberg, S., Bilheimer, D. W., Phair, R. D., and Goebel, R. H., 1978, Metabolism of apo B and apo C lipoproteins in man: Kinetic studies in normal and hyperlipoproteinemic subjects, J. Lipid Res. 19:38–56.Google Scholar
- Cheung, M., and Albers, J. J., 1982, Distribution of high density lipoprotein particles with different apoprotein composition: Particles with AI and AII and particles with AI but no AII, J. Lipid Res. 23:747–753.Google Scholar
- Krauss, R. M., and Burke, D. J., 1982, Identification of multiple subclasses of plasma LDL in normal humans, J. Lipid Res. 23:97–104.Google Scholar
- Schaefer, E. J., Zech, L. A., Jenkins, L. L., Bronzert, T. J., Rubacaba, E. A., Lindgren, F. J., Aamodt, R. L., and Brewer, H. B., 1982, Human apolipoprotein AI and AII metabolism, J. Lipid Res. 23:850–858.Google Scholar
- Shepherd, J., and Packard, C. J., 1984, High density lipoprotein apolipoprotein metabolism, in: Clinical and Metabolic Aspects of High Density Lipoproteins (N. E. Miller and G. J. Miller, eds.), Elsevier, Amsterdam, pp. 247–274.Google Scholar
- Shepherd, J., Packard, C. J., Stewart, J. M., Atmeh, R. F., Clark, R. S., Boag, D. E., Carr, K., Lorimer, A. R., Ballantyne, D., Morgan, H. G., and Lawrie, T. D. V., 1984, Apolipoprotein A and B (Sf 100–400) metabolism during bezafibrate therapy in hypertriglyceridemic subjects, J. Clin. Invest. 74:2164–2177.CrossRefGoogle Scholar
- Weisgraber, K. H.Mahley, R. W., 1980, Subfractionation of human high density lipoproteins by heparin-sepharose affinity chromatography, J. Lipid Res. 21:316–325.Google Scholar