Evaluation of Xenobiotic Metabolism

  • James R. Gillette
  • Ronald W. Estabrook
Part of the Life Science Monographs book series (LSMO)


In the broadest sense of the word, a toxicant is any substance that causes changes in the function, structure, or replication of cells or the maintenance of homeostasis in a tissue of any living organism. Ordinarily, a toxicant is considered to be a substance in the environment that gains entrance into the body by inhalation, ingestion, injection, or absorption. But a toxicant may also be formed within the organism. Indeed, it may be a neurotransmitter, a hormone, or a metabolic acid that at low concentrations plays a vitally important role in maintaining the wellbeing of the organism, but at higher concentrations triggers an abnormal response.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • James R. Gillette
    • 1
  • Ronald W. Estabrook
    • 2
  1. 1.Laboratory of Chemical PharmacologyNational Heart, Lung, and Blood InstituteBethesdaUSA
  2. 2.Department of Biochemistry, Southwestern Medical SchoolUniversity of Texas Health Science CenterDallasUSA

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