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The Chemical and Biological Properties of PAF Agonists, Antagonists, and Biosynthetic Inhibitors

  • T. Y. Shen
  • San-Bao Hwang
  • Thomas W. Doebber
  • James C. Robbins

Abstract

As PAF was being characterized as a highly potent lipid mediator of inflammation and anaphylaxis, its unusual structure stimulated considerable interest in the investigation of various structural analogs, initially to define the structure requirement for its biological actions, and later to explore the possibility of dissociating its cardiovascular, pulmonary, and renal activities. More recently, the possible existence of multimolecular species of PAF-like molecules in vivo is also being investigated.

Keywords

Platelet Activate Factor Rabbit Platelet Soluble Immune Complex Phospholipid Analog Rabbit Platelet Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • T. Y. Shen
    • 1
  • San-Bao Hwang
    • 1
  • Thomas W. Doebber
    • 1
  • James C. Robbins
    • 1
  1. 1.Departments of Membrane and Arthritis Research and Biochemical RegulationMerck, Sharp & Dohme Research LaboratoriesRahwayUSA

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