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Enzymatic Pathways for Platelet-Activating Factor, Related Alkyl Glycerolipids, and Their Precursors

  • Fred Snyder

Abstract

The purpose of this chapter is to provide a succinct overview of the enzymatic reaction steps for alkyl glycerolipids and lipid precursors affiliated with the biosynthesis and catabolism of platelet-activating factor (PAF). Only the principal distinguishing features of the enzymes are summarized since detailed coverage of the metabolism of PAF (Lee and Snyder, 1985; Snyder, 1982, 1985a) and of ether lipids in general (Hajra, 1983; Horrocks and Sharma, 1982; Snyder, 1985b; Snyder et al., 1985a) has appeared in recent reviews or is discussed in other chapters of this book. This presentation is intended to serve as a quick and concise reference to the individual enzymatic reactions involving PAF and related ether-linked lipids. A composite pathway that illustrates the interrelationship of these reaction steps is also included.

Keywords

Platelet Activate Factor Fatty Alcohol Enzymatic Pathway Ether Lipid Glyceryl Ether 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DTT

dithiothreitol

PAF

platelet-activating factor l-alkyl-2-acetyl-sn-glycero-3-phosphocholine

DHAP

dihydroxyacetone-P

DHA

dihydroxyacetone

SHR

spontaneous hypertensive rat

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References

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Fred Snyder
    • 1
  1. 1.Medical and Health Sciences DivisionOak Ridge Associated UniversitiesOak RidgeUSA

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