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Antineoplastic Actions of Ether Lipids Related to Platelet-Activating Factor

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Platelet-Activating Factor and Related Lipid Mediators

Abstract

Many inorganic and organic biological response modifiers, which stimulate host defense mechanisms against infections and tumors (Oldham, 1982), share one biochemical effect. After phagocytosis by macrophages, they activate or induce a phospholipase A2 (E.C. 3.1.1.4) which degrades cellular phosphatidylcholine and phosphatidylethanolamine to the corresponding lyso compounds as 2-lysophospha-tidylcholine (2-LPC) and free fatty acids (Munder and Modolell, 1974; Munder et al., 1966, 1969, 1970, 1976). Compounds without immunopotentiating capacity do not alter the activity of phospholipase A2 (Munder et al., 1976).

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Author information

Authors and Affiliations

  1. Division of Hematology and Oncology, Department of Medicine I, Technical University, Munich, Federal Republic of Germany

    Wolfgang E. Berdel

  2. Max Planck Institute for Immunobiology, Freiburg, Federal Republic of Germany

    Paul G. Munder

Authors
  1. Wolfgang E. Berdel
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  2. Paul G. Munder
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Editors and Affiliations

  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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© 1987 Plenum Press, New York

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Berdel, W.E., Munder, P.G. (1987). Antineoplastic Actions of Ether Lipids Related to Platelet-Activating Factor. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_21

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  • DOI: https://doi.org/10.1007/978-1-4684-5284-6_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5286-0

  • Online ISBN: 978-1-4684-5284-6

  • eBook Packages: Springer Book Archive

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