The Role of Platelet-Activating Factor in Inflammation

  • Giovanni Camussi
  • Jan R. Brentjens


Inflammation and hypersensitivity reactions are reactions of vascularized tissue to exogenous or endogenous noxa. Inflammation suggests a protective, immunologically or nonimmunologically mediated response that tends first to localize and then to neutralize noxious material. The inflammatory response is strictly intertwined with a complex series of events that serve to heal and repair the damaged tissue. However, inflammation and repair may be potentially harmful. Hypersensitivity reactions imply an incongruous or sustained activation of the immunologic reactions involved in the inflammatory response, which results not in protection, but in destruction of tissue integrity.


Immune Complex Hypersensitivity Reaction Glomerular Capillary Wall Systemic Anaphylaxis Acute Poststreptococcal Glomerulonephritis 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Giovanni Camussi
    • 1
    • 2
  • Jan R. Brentjens
    • 1
    • 2
  1. 1.Laboratory of Immunopathology, Chair of NephrologyUniversity of TurinTurinItaly
  2. 2.Departments of Microbiology, Pathology, and MedicineState University of New YorkBuffaloUSA

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