Introduction Historical Aspects of Alkyl Lipids and Their Biologically Active Forms (Ether Lipids, Platelet-Activating Factor, and Antihypertensive Renal Lipids)
This introduction reviews highlights of key historical developments that have occurred in research with alkyl ether glycerolipids, platelet-activating factor (PAF), and a group of renal antihypertensive lipids. It is not intended to represent an exhaustive survey of the literature, but instead attempts to explain how the three areas became integrated. The period of history covered (Fig. 1) ranges from the 1920s, when the alkyl lipids were first detected in fish, to 1980, when proof of the chemical structure and the enzymatic pathways for the biosynthesis of PAF were established.
KeywordsRenal Medulla Ether Lipid Glyceryl Ether Alkyl Ether Rabbit Platelet
Unable to display preview. Download preview PDF.
- Benveniste, J., Tence, M., Varenne, P., Bidault, J., Boullet, C., and Polonsky, J., 1979, Semi-synthese et structure purposee du facteur activant les plaquettes (P.A.F.); PAF-acether, un alkyl ether analogue de la lysophosphatidylcholine, C. R. Acad. Sci. [D], (Paris) 289:1037–1040.Google Scholar
- Heilbron, I. M., and Owens, W. M., 1928, The unsaponifiable matter from the oils of elasmobranch fish. Part IV. The establishment of the structure of selachyl and batyl alcohols as monoglyceryl ethers, J. Chem. Soc. ,p. 942–947.Google Scholar
- Muirhead, E. E., Leach, B. E., Byers, L. W., Brooks, B. Daniels, E. G., and Hinman, J. W., 1971, Antihypertensive renomedullary lipids (ANRL), in: Kidney Hormones ,(J. W. Fisher, ed.), Academic Press, New York, pp. 485–506.Google Scholar
- Muirhead, E. E., Leach, B. E., Bycrs, L. W., and Brooks, B., 1976, Enhanced potency of depressor renomedullary lipid, Circulation 54:11–175 (Abstr. 0683),Google Scholar
- Renooij, W., Wykle, R. L., Blank, M. L., Lee, T-C., Malone, B., Fitzgerald, V., and Snyder, F., 1980, Metabolism of l-alkyl-2-acetoyl-sn-glycero-3-phosphocholine, an antihypertensive phospholipid, Fed. Proc. 39:2187 (Abstr. 3059).Google Scholar
- Toyama, Y., 1924a, Oleic alcohol, Chem. Umschau 31:13–17.Google Scholar
- Toyama, Y., 1924b, Unsaponifiable constituents (higher alcohol) of shark and ray-liver oil, III. Chem. Umschau 31:61–70.Google Scholar
- Toyama, Y., 1924c, Unsaponifiable constituents (higher alcohol) of shark and ray-liver oil, IV. Chem. Umschau 31:153–155.Google Scholar
- Tsujimoto, M., and Toyama, Y., 1922, The unsaponifiable constituents (higher alcohol) of the liver oil of sharks and rays, Chem. Umschau 29:27–29, 43–45.Google Scholar