Cytoskeleton pp 267-283 | Cite as

Neoplastic Transformations

Possible Unexplored Functions of Cytoskeleton
  • Alexander D. Bershadsky
  • Juri M. Vasiliev
Part of the Cellular Organelles book series (CORG)


There are at least two reasons why neoplastic transformations of one particular cell type, cultured fibroblasts, deserve special discussion in a book on the cytoskeleton. First, these transformations are the best-studied genetic changes of cells of higher eukaryotes, manifested by alterations of morphogenesis. Therefore, analysis of these changes can help further our understanding of the mechanisms of regulation of morphogenesis. Second, neoplastic transformations are manifested not only by morphological changes, but also by alterations of growth regulation. Therefore, analysis of the expression of neoplastic transformations can help to reveal the possible relationship of the cytoskeleton to this regulation and, more generally, to the control of biochemical reorganizations of the cell.


Focal Contact Rous Sarcoma Virus Chicken Embryo Fibroblast Inositol Triphosphate Salivary Gland Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Alexander D. Bershadsky
    • 1
  • Juri M. Vasiliev
    • 1
  1. 1.Cancer Research CenterMoscow State UniversityMoscowUSSR

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