There are at least two reasons why neoplastic transformations of one particular cell type, cultured fibroblasts, deserve special discussion in a book on the cytoskeleton. First, these transformations are the best-studied genetic changes of cells of higher eukaryotes, manifested by alterations of morphogenesis. Therefore, analysis of these changes can help further our understanding of the mechanisms of regulation of morphogenesis. Second, neoplastic transformations are manifested not only by morphological changes, but also by alterations of growth regulation. Therefore, analysis of the expression of neoplastic transformations can help to reveal the possible relationship of the cytoskeleton to this regulation and, more generally, to the control of biochemical reorganizations of the cell.
KeywordsFocal Contact Rous Sarcoma Virus Chicken Embryo Fibroblast Inositol Triphosphate Salivary Gland Extract
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