Practical and Ethical Aspects of Pharmacotherapeutic Evaluation

  • David R. Rubinow


Premenstrual syndrome exemplifies the convergence of science and superstition, experience and belief, political consciousness and political subjugation, inquiry and ideology. The current state of confusion surrounding this disorder impacts on the decisions made regarding its treatment. In the following paper, I will pose a series of questions about the ethical and practical principles of pharmacotherapeutic evaluation with specific reference to the premenstrual syndrome(s) (PMS).


Premenstrual Syndrome Progesterone Treatment Placebo Response Rate Premenstrual Tension Luteal Phase Defect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abplanalp, J. M., A. F. Donnelly, and R. M. Rose, 1979. Psychoendo-crinology of menstrual cycle, I Enjoyment of daily activities and moods. Psychosomatic Medicine 41 587–604.PubMedGoogle Scholar
  2. Abraham, G. E., 1980. The premenstrual tension syndromes. In L. K. McNall (Ed.), Contemporary Obstetric and Gynecologic Nursing, Vol. 3. Mosby Co., St. Louis, MO.Google Scholar
  3. Dalton, K., 1964. The Premenstrual Syndrome. Charles C. Thomas, Springfield, IL.Google Scholar
  4. Endicott, J. and U. Halbreich, 1982. Psychobiology of premenstrual change. Psycho pharmacology Bulletin 18 109–112.Google Scholar
  5. Halbreich, U., J. Endicott, S. Schacht, and J. Nee, 1982. The diversity of premenstrual changes as reflected in the Premenstrual Assessment Form. Acta Psychiatric a Scandinavica 65 46–65.CrossRefGoogle Scholar
  6. Hare, R. M., 1964. The Language of Morals. Oxford University Press, New York, NY.Google Scholar
  7. Hare, R. M., 1965. Freedom and Reason. Oxford University Press, New York, NY.CrossRefGoogle Scholar
  8. Haskett, R. F., M. Steiner, J. N. Osmun, and B. J. Carroll, 1980. Severe premenstrual tension Delineation of the syndrome. Psychiatry 15 121–139.Google Scholar
  9. Kramp, J. L., 1968. Studies of the premenstrual syndrome in relation to psychiatry. Acta Psychiatrica Scandinavica (Suppl.) 203 261–267.CrossRefGoogle Scholar
  10. McCance, R. A., R. C. Luff, and E. Widdowson, 1937. Physical and emotional periodicity in women. Journal of Hygiene (London) 37 571–611.PubMedCrossRefGoogle Scholar
  11. Parlee, M. B., 1973. The premenstrual syndrome. Psychological Bulletin 80 454–465.PubMedCrossRefGoogle Scholar
  12. Rubinow, D. R. and P. P. Roy-Byrne, 1984. Premenstrual syndromes Overview from a methodologic perspective. American Journal of Psychiatry 141 161–172.Google Scholar
  13. Rubinow, D. R., P. P. Roy-Byrne, M. C. Hoban, P. W. Gold, and R. M. Post, 1984. Prospective assessment of menstrually-related mood disorders. American Journal of Psychiatry 141 684–686.PubMedGoogle Scholar
  14. Rubinow, D. R., P. P. Roy-Byrne, M. C. Hoban, G. N. Grover, N. Stambler, and R. M. Post, 1986. Premenstrual mood changes Characteristic patterns in women with and without premenstrual syndrome. Journal of Affective Disorders ,in press.Google Scholar
  15. Ruble, D. N. and J. Brooks-Gunn, 1979. Menstrual symptoms A social cognition analysis. Journal of Behavioral Medicine 2 171–194.PubMedCrossRefGoogle Scholar
  16. Sampson, J. A. and P. Prescott, 1981. The assessment of the symptoms of premenstrual syndrome and their response to therapy. British Journal of Psychiatry 138 399–405.PubMedCrossRefGoogle Scholar
  17. Sutherland, H. and 1. Stewart, 1965. A critical analysis of premenstrual syndrome. The Lancet 1 1180–1183.CrossRefGoogle Scholar
  18. Taylor, J. W., 1979. The timing of menstruation-related symptoms assessed by a daily symptom rating scale. Acta Psychiatric a Soandinavica 60 87–105.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • David R. Rubinow
    • 1
    • 2
  1. 1.Psychiatry Consultation-LiaisonNational Institutes of HealthBethesdaUSA
  2. 2.Unit on Peptide Studies, Biological Psychiatry BranchNational Institute of Mental HealthBethesdaUSA

Personalised recommendations