Dysphoric Premenstrual Changes: Are They Related to Affective Disorders?

  • Uriel Halbreich
  • Jean Endicott


Some investigators hope to study premenstrual changes (PMC) as a model for more severe affective disorders. The use of premenstrual depression as a model for affective disorder is supported by studies that have found: (1) a differential and positive relationship between premenstrual depressive changes and a lifetime diagnosis of affective disorder, as compared with a lifetime diagnosis of no mental disorder or some other mental disorders (Coppen, 1965; Diamond, Rubinstein, Dunner, & Fieve, 1976; Kashiwagi, McClure, Reich, & Wetzel, 1976; Schuckit, Daly, Herrman, & Hineman, 1975; Wetzel, Reich, McClure, & Wald, 1975); (2) that some women experience a depressive syndrome during the premenstrual period severe enough to seek treatment for the condition (reviewed by Halbreich & Endicott, 1985a); (3) that suicide attempts and admissions to psychiatric hospitals for depressive episodes are associated with the paramenstrual period (Abramowitz, Backer, & Freischer, 1982); and (4) that premenstrual exacerbation of depressive syndromes is seen in those with depressive disorders.


Major Depressive Disorder Affective Disorder Major Depressive Disorder Premenstrual Syndrome Depressive Syndrome 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Uriel Halbreich
    • 1
  • Jean Endicott
    • 2
  1. 1.Department of PsychiatrySUNYBuffaloUSA
  2. 2.New York Psychiatric InstituteNew YorkUSA

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