Density Modification Methods

  • A. D. Podjarny
Part of the NATO ASI Series book series (NSSA, volume 126)


Macromolecular crystallography is growing rapidly as a tool to image the structure of proteins, nucleic acids and their interactions . In many of these projects, however, MIR (Multiple Isomorphous Replacement) phasing methods have not been successful in imaging macromolecules within their crystals. These problems have motivated efforts to supplement or replace MIR as a phasing technique. Various approaches have been tried, both in real and reciprocal space, and among them DM (density modification) methods have proven to be quite succesful in improving phases using real-space constraints.


Reciprocal Space Acta Cryst Calculated Phase Density Modification Original Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • A. D. Podjarny
    • 1
  1. 1.Dept. of Biochemistry and Molecular BiologyU. of ChicagoChicagoUSA

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