Periplasmic Binding Proteins: Structures and New Understanding of Protein-Ligand Interactions

  • F. A. Quiocho
  • N. K. Vyas
  • J. S. Sack
  • M. A. Storey
Part of the NATO ASI Series book series (NSSA, volume 126)


The molecular approach to the study of active transport in bacteria has led to the identification of a group of proteins referred to as “binding proteins”, which are initial components of high affinity transport systems for a large variety of carbohydrates, amino acids, and ions. Several of the sugar-binding proteins also act as initial receptors for bacterial chemotaxis. These proteins, which are located in the periplasmic space, exhibit monomeric molecular weights in the range of 25,000 to 45,000 and contain one tight ligand binding site with dissociation constants of about 0.1 µM.


Periplasmic Binding Protein Ligand Site Hydrogen Bond Donor Group Monomeric Molecular Weight Average Hydrogen Bond 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • F. A. Quiocho
    • 1
  • N. K. Vyas
    • 1
  • J. S. Sack
    • 1
  • M. A. Storey
    • 1
  1. 1.Department of BiochemistryRice UniversityHoustonUSA

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