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Errors in DNA Helices: G.T Mismatches in the A, B and Z Forms of DNA

  • Dov Rabinovich
Part of the NATO ASI Series book series (NSSA, volume 126)

Abstract

DNA replication is perhaps the most specific of all enzymic processes. Genetic experiments in DNA replication of E. Coli indicate an error range of one mistake in 10 million to 100 billion nucleotide polymerized. This remarkable fidelity is essential in order to preserve the genetic identtity of organisms. Yet, a few errors must be permitted for species evolution and adaptation to changing environments. Mutagenesis appears also to be important in determining the life cycle of individual organisms, as it is central to many pathological processes.

Keywords

Enol Tautomer Wobble Pair Deoxyribose Moiety Mispaired Base Pair Geometry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Loeb, A.L. and Kinkel, T.A., Ann. Rev. Biochem., 51:429 (1982).PubMedCrossRefGoogle Scholar
  2. 2.
    Goodman, M.F., Hopkins, R.L., Watanabe, S.M., Clayton, L.K. and Guidotti, S., in: ’Mechanistic Studies of DNA Recombination’, Eds. Alberts, B. and Fox, F.F., Academic Press, New York, p.685 (1980).CrossRefGoogle Scholar
  3. 3.
    Fersht, A.R., Knill-Jones, J.W. and Tsui, W.-C, J.Mol.Biol. 156:37 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    Watson, J.D. and Crick, F.H.C., Nature, 171:737 (1953).PubMedCrossRefGoogle Scholar
  5. 5.
    Topal, M.D. and Fresco, J.R., Nature, 263:285 (1976).PubMedCrossRefGoogle Scholar
  6. 6.
    Crick, F.H.C, J. Mol. Biol., 19:548 (1976).CrossRefGoogle Scholar
  7. 7.
    Ladner, J.E., Jack, A., Robertus, J.D., Brown, R.S., Rhodes, D., Clark, B.F.C. and Klug, A., Nucl. Acids Res., 2:1629 (1975).PubMedCrossRefGoogle Scholar
  8. 8.
    Quigley, G.J., Seeman, N.C., Wang, A.H.-J., Suddath, F.L. and Rich, A., Nucl. Acids Res., 2:2329 (1975).PubMedCrossRefGoogle Scholar
  9. 9.
    Sussman, J.L. and Kim, S.-H., Biochem. Biophys. Res. Commun., 68: (1976).Google Scholar
  10. 10.
    Patel, D.J., Koslowski, S.A., Ikuta, S., and Itakura, K., Fed. Proc, 43:2663 (1984).PubMedGoogle Scholar
  11. 11.
    Chuprina, V.P. and Poltev, V.I., Nucl. Acids Res., 11:5205 (1983).PubMedCrossRefGoogle Scholar
  12. 12.
    Rein, R., Shibita, M., Garduno-Juarez, R. and Kieber-Emmons, T., in: ‘Structure and Dynamics: Nucleic Acids and Proteins’, Eds. Clementi, E. and Sarma, R.H., Academic Press, New York (1983).Google Scholar
  13. 13.
    Gaits, M.J., Matthes, H.W.D., Singh, M., Sproat, B.S. and Titmus, R.C., Nucl. Acids Res., 10:6243 (1982).CrossRefGoogle Scholar
  14. 14.
    Rabinovich, D. and Shakked, Z., Acta Cryst., A4O:195 (1984).Google Scholar
  15. 15.
    Sussman, J.L., Holbrook, S.R., Church, G.M. and Kim, S.-H., Acta Cryst., A33:8OO (1977).Google Scholar
  16. 16.
    Brown, T., Kennard, O., Kneale, G. and Rabinovich, D., Nature, 315:605 (1985).Google Scholar
  17. 17.
    Kneale, G., Brown, T., Kennard, O., and Rabinovich, D., Sbumitted to J. Mol. Biol. (1985).Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Dov Rabinovich
    • 1
  1. 1.Department of Structural ChemistryThe Weizmann Institute of ScienceRehovotIsrael

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