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The Structure of a Human Common Cold Virus (Rhinovirus 14) and its Functional Relations to Other Picornaviruses

  • Michael G. Rossmann
  • Edward Arnold
  • John W. Erickson
  • Elizabeth A. Frankenberger
  • James P. Griffith
  • Hans-Jürgen Hecht
  • John E. Johnson
  • Greg Kamer
  • Ming Luo
  • Anne G. Mosser
  • Roland R. Rueckert
  • Barbara Sherry
  • Gerrit Vriend
Part of the NATO ASI Series book series (NSSA, volume 126)

Abstract

Picornaviruses are associated with serious diseases in humans and other animals, and they comprise one of the largest families of viral pathogens. For example, the common cold, poliomyelitis, foot-and-mouth disease and hepatitis can be caused by these viruses. They are among the smallest RNA-containing animal viruses (1–3). Their molecular weight is a round 8.5 x 106 and they contain about 30% by weight RNA. Their external diameter is roughly 300 Å and they form icosahedral shells. Picornaviridae have been subdivided into four genera on the basis of their buoyant density, pH stability and sedimentation coefficients: enterovirus (e . g . polio, hepatitis A and coxsackie viruses), cardiovirus (e .g . encephalomyocarditis and Mengo viruses), aphthovirus (e.g. foot-and-mouth disease virus) and rhinovirus . They differ also in the number of known serotypes. For instance there are three known serotypes for polioviruses, seven for foot-and- mouth disease viruses (FMDV) and at least 89 for human rhinoviruses (HRV). Accordingly, it has been possible to produce effective vaccines for poliomyelitis and, with greater difficulty , for foot-and-mouth disease, but not for the common cold.

Keywords

Human Rhinovirus Icosahedral Symmetry Tomato Bushy Stunt Virus Poliovirus Type Canyon Wall 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Michael G. Rossmann
    • 1
  • Edward Arnold
    • 1
  • John W. Erickson
    • 1
  • Elizabeth A. Frankenberger
    • 1
  • James P. Griffith
    • 1
  • Hans-Jürgen Hecht
    • 1
  • John E. Johnson
    • 1
  • Greg Kamer
    • 1
  • Ming Luo
    • 1
  • Anne G. Mosser
    • 2
  • Roland R. Rueckert
    • 2
  • Barbara Sherry
    • 2
  • Gerrit Vriend
    • 1
  1. 1.Department of Biological SciencesPurdue UniversityW. LafayetteUSA
  2. 2.Biophysics LabUniversity of WisconsinMadisonUSA

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