The Role of Separate Domains and of Individual Amino-Acids in Enzyme Catalysis, Studied by Site-Directed Mutagenesis

  • D. M. Blow
  • P. Brick
  • K. A. Brown
  • A. R. Fersht
  • G. Winter
Part of the NATO ASI Series book series (NSSA, volume 126)


Protein engineering is the production of a novel or altered protein — a ‘factitious’ protein — by the creation or manipulation of a gene which controls its synthesis, for a specific purpose. To achieve the intended purpose, an ability to predict the properties of the factitious protein is required.


TP51 Mutant Protein Engineering Factitious Protein Protein Crystallography Main Chain Conformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • D. M. Blow
    • 1
  • P. Brick
    • 1
  • K. A. Brown
    • 1
  • A. R. Fersht
    • 2
  • G. Winter
    • 3
  1. 1.Blackett LaboratoryImperial CollegeLondonUK
  2. 2.Department of ChemistryImperial CollegeLondonUK
  3. 3.Laboratory of Molecular BiologyMRC CentreCambridgeEngland

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